【摘要】 既往研究认为骨骼的主要功能包括:机械支持、保护重要器官、提供造血微环境、参与钙磷代谢。近年越来越多的证据表明,骨骼不仅是接受神经和体液调节的"惰性器官",而且是具有生物活性的"内分泌器官"。骨骼分泌的生物活性物质,如骨调节蛋白、生长因子、脂肪因子、细胞因子、活性多肽和激素等,能通过自分泌、旁分泌的方式调节骨的代谢,也能以远距分泌的方式作用于胰腺、肝脏、肾脏、骨骼肌、大脑、睾丸等靶器官或组织,发挥相应的生物学作用。更多还原

【Abstract】 For a long time, only classical actions have been attributed to the skeleton such as protection and stabilization of the body and support in locomotion. In addition, bone is a site for hematopoiesis and serves as a pivotal organ in calcium and phosphorus homeostasis. In recent years, more and more evidence has shown that bone is not only an "inert organ"accepting neurological and humoral regulation, but also an"endocrine organ"with biological activity. Biologically active substances secreted by bone, such as bone regulatory protein, growth factors, adipokines, cytokines, active peptides and hormones, can regulate the metabolism of bone through autocrine and paracrine pathways. It can also act on the target organs or tissues such as the pancreas, liver, kidney, skeletal muscle, brain, testis through telecrine pathway.更多还原