【摘要】 能量代谢异常是肿瘤细胞的重要特征之一。即使在氧气充足的条件下,高速糖酵解取代氧化磷酸化为肿瘤细胞供能。肿瘤细胞在缺氧微环境、癌症相关基因及信号通路等因素驱动下进行代谢重编程,在满足自身能量需求的同时获得快速增殖所需要的生物大分子及还原力等基础物质,为肿瘤细胞提供了缺氧条件下的生长优势。由不同代谢表型的细胞亚群构成的实体肿瘤具有代谢异质性的特征。本文将综述肿瘤细胞糖代谢重编程的因与果及其代谢异质性,为靶向肿瘤代谢的个体化治疗寻找新的有效靶点。更多还原

【Abstract】 Aberrant energy metabolism is an important feature of tumor cells. Even with ample oxygen supply, most tumor cells prefer enhanced glycolysis instead of oxidative phosphorylation to produce ATP. Hypoxia microenvironment, cancer related genes together with signaling pathways drive metabolism alteration in tumor cells. The metabolism reprogram provides energy, biological materials and NADPH as well, which offers growth advantage for tumor cells under hypoxia. Solid tumors constituted of diversely-reprogrammed cell subsets behave heterogeneous metabolism phenotype. In this review, we would focus on reprogram and heterogeneity of tumor glucose metabolism to discover new targets for individual therapy targeting tumor metabolism.更多还原