【摘要】 目的观察中药联合尼可地尔治疗气虚血瘀型稳定性心绞痛的临床疗效,为气虚血瘀型稳定性心绞痛的治疗提供有效的治疗方法。方法选取2015年1月至2017年8月就诊于河北省民政总医院心内科的气虚血瘀型稳定性心绞痛患者163例,随机分为3组,对照组55例给予心绞痛常规治疗,观察A组53例在对照组的基础上给予尼可地尔口服,观察B组55例在观察A组的基础上给予自拟中药组方治疗,治疗4周,观察治疗前后心绞痛发作次数、持续时间,硝酸甘油的用量,血清同型半胱氨酸(Hcy)和高敏C反应蛋白(hs-CRP)的变化,评价疾病的疗效。结果 3组患者用药后心绞痛发作次数、持续时间、硝酸甘油用量均较本组治疗前减少(P <0. 05);治疗后3组患者心绞痛发作次数、持续时间及硝酸甘油用量比较差异有统计学意义;观察B组患者心绞痛发作次数最少、持续时间最短、硝酸甘油用量最小。观察B组疾病疗效明显优于对照组(P <0. 05)。3组患者治疗后Hcy和hs-CRP值均较治疗前降低(P <0. 05),治疗后3组患者Hcy和hs-CRP值比较差异有统计学意义,观察B组患者Hcy和hs-CRP值降低更为明显(P <0. 05)。结论中药联合尼可地尔治疗气虚血瘀型稳定性心绞痛可以减少心绞痛发作次数,缩短心绞痛持续时间,减少硝酸甘油用量,提高疾病疗效,降低Hcy和hs-CRP水平。更多还原

【Abstract】 Objective To observe the clinical effects on stable angina pectoris of qi deficiency and blood stagnation type treatment with Chinese medicine and nicorandil so as to provide the effective therapeutic method for the treatment of stable angina pectoris of qi deficiency and blood stagnation type. Methods From January 2015 to August 2017,163 patients treated in Department of Cardiology,Hebei Civil Administration Hospital were randomized into three groups. 55 cases in the control group( 55 cases) were treated with the routine therapy. 53 cases in the observation A group were with the oral administration of nicorandil on the base of the treatment as the control group. 55 cases in the observation B group,were treated with the self-prepared Chinese herbal formula on the base of the treatment as the observation A group. The treatment lasted for 4 weeks. Before and after treatment,the attack frequency,persistent time,the dosage of nitroglycerin and the changes of Hcy and hs-CRP were observed before and after treatment. The therapeutic effects were evaluated. Results After medication,the attack frequency,persistent time,the dosage of nitroglycerin and the changes of Hcy and hs-CRP were all reduced as compared the results before treatment in the three groups( P < 0. 05). After treatment,these results were different significantly among the three groups. These results in the observation B group were the lowest. Therapeutic effects in the observation B group were obviously better than the control group( P < 0. 05). After treatment,Hcy and hs-CRP values were all reduced as compared with the values before treatment in the three groups( P < 0. 05). The differences were significant among the three groups after treatment. Hcy and hs-CRP values were reduced more obviously in the observation B group( P < 0. 05). Conclusion The combined medication of Chinese medicine and nicorandil reduces the attack frequency,shortens the persistent duration,reduces the dosage of nitroglycerin,improves the therapeutic effects and reduces the levels of Hcy and hs-CRP in the patients of stable angina pectoris of qi deficiency and blood stagnation type.更多还原