【摘要】 目的探索手足口病合并细菌感染的临床特征与免疫功能变化关系。方法选取2017年4月—2018年4月期间收治的健康组50名健康体检者、对照组50例单纯细菌感染患儿、观察组50例手足口病合并细菌感染患儿,对所有受检者进行ALT、IL-6、IL-10、CD19+、WBC、CRP、GIu、PCT、CK-MB、IgM、IgG、IgA、CD8+、CD4+、CD3+检测。结果两组在对比肺出血、抽搐、皮疹等症状时均差异无统计学意义(χ2=0.325 1、0.154 1、1.586 1;P>0.05),但在对比嗜睡、呕吐、惊跳、重症时(χ2=8.984 1、6.844 1、12.854 1、8.094 1;P<0.05),同时观察组CD19+(28.95±2.36)%、IgM (1.89±1.38)g/L、IgG (8.95±0.65)g/L、IgA (1.85±0.68)g/L、WBC(16.85±2.43)×109/L、CRP (23.86±2.19)mg/L、GIu (8.75±1.36)mmol/L、PCT (6.87±0.42)ng/L、CK-MB (42.89±2.69)U/L、ALT (40.57±2.41)U/L、IL-6(4.85±1.93)pg/mL、IL-10(66.85±3.29)pg/mL高于对照组、健康组(t=4.021 5、2.369 5、4.132 5、1.855 4、3.658 4、3.632 5、3.136 2、3.236 5、4.128 5、4.039 8、4.032 8、4.398 5;P<0.05),CD8+(17.45±1.32)%、CD4+(28.39±1.48)%、CD3+(52.15±3.19)%低于对照组、健康组(t=3.021 5、2.539 2、3.854 2;P<0.05)。结论手足口病合并细菌感染患儿病情加重与机体体液免疫紊乱、细胞免疫紊乱有关,通过尽早实施细胞学检验,能够防止病情恶化。更多还原

【Abstract】 Objective To explore the relationship between clinical features and immune function of bacterial infection in hand, foot and mouth disease. Methods 50 healthy subjects in the healthy group, 50 patients with simple bacterial infection, and 50 patients with hand, foot and mouth disease and bacterial infection in the observation group were selected from April, 2017 to April, 2018. ALT, IL-6, IL-10, CD19+, WBC, CRP, GIu, PCT, CK-MB, IgM, IgG, IgA, CD8+, CD4+, CD3+ were detected in all subjects. Results There was no difference between the two groups in comparing pulmonary hemorrhage, convulsions, rash and other symptoms(χ2=0.325 1,0.154 1, 1.586 1; P>0.05), but there was a comparison between lethargy, vomiting, startle, and severe illness, significant differences(χ2=8.984 1, 6.844 1, 12.854 1, 8.094 1; P<0.05), while observation group CD19+(28.95±2.36)%, IgM(1.89±1.38) g/L, IgG(8.95±0.65) g/L, IgA(1.85±0.68) g/L, WBC(16.85±2.43)×109/L, CRP(23.86±2.19) mg/L, GIu(8.75±1.36) mmol/L, PCT(6.87±0.42))ng/L,CK-MB(42.89±2.69) U/L, ALT(40.57±2.41) U/L, IL-6(4.85±1.93) pg/mL, IL-10(66.85±3.29) pg/mL, higher than the control group and healthy group(t=4.021 5, 2.369 5, 4.132 5, 1.855 4, 3.658 4, 3.632 5, 3.136 2, 3.236 5, 4.128 5, 4.039 8, 4.032 8, 4.398 5; P<0.05), CD8+(17.45±1.32)%, CD4+(28.39±1.48)% and CD3+(52.15±3.19)% were lower than the control group and healthy group(t=3.021 5, 2.539 2, 3.854 2; P<0.05). Conclusion The severity of hand, foot and mouth disease with bacterial infection is related to the body’s humoral immune disorder and cellular immune disorder. By performing cytological examination as early as possible, it can pre-vent the disease from worsening.更多还原