【摘要】 目的探讨降尿酸方联合别嘌醇治疗脾肾气虚兼湿热内蕴型尿酸性肾病的临床疗效。方法将60例脾肾气虚兼湿热内蕴型尿酸性肾病患者随机分为治疗组和对照组,每组30例。两组均予别嘌醇片口服,治疗组在此基础上加服降尿酸方。两组疗程均为28天,观察临床疗效,比较血尿酸、血肌酐、血尿素氮、肾小球滤过率、尿β2微球蛋白、N-乙酰基-β-D氨基葡糖苷酶、24 h尿蛋白定量的变化情况。结果 (1)治疗组、对照组总有效率分别为80.0%、50.0%;组间临床疗效比较,治疗组明显优于对照组(P<0.05)。(2)与本组治疗前比较,治疗组血尿酸、血肌酐、尿β2微球蛋白、N-乙酰基-β-D氨基葡糖苷酶、24 h尿蛋白定量水平下降(P<0.05),肾小球滤过率明显提高(P<0.05),对照组仅血尿酸水平下降(P<0.05);组间治疗后比较,上述各指标差异均有统计学意义(P<0.05)。结论降尿酸方联合别嘌醇治疗脾肾气虚兼湿热内蕴型尿酸性肾病,不仅能明显降低血尿酸水平,还可改善肾小球滤过功能、肾小管修复功能,降低尿蛋白水平。更多还原

【Abstract】 Objective To discuss the clinical efficacy of Uric acid-reducing Decoction combined with allopurinol in the treatment of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior. Methods Sixty patients of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior were randomly divided into the treatment group and control group,30 cases in each group. Both groups were orally treated with allopurinol tablets,and the treatment group was additionally treated with Uric acid-reducing Decoction,with a course of28 days. The clinical efficacy was observed. The changes on uric acid,creatinine and urea nitrogen levels in serum,glomerular filtration rate,urinary β2 microglobulin,N-acetyl-β-D glucosaminidase and 24 h urine protein quantity were compared. Results(1)The total effective rates were 80.0% in the treatment group and 50.0% in the control group,the clinical efficacy of the treatment group was better than that of the control group(P<0.05).(2)Compared with treatment before,the levels of serum uric acid,serum creatinine,urinary β2 microglobulin,N-acetyl-β-D glucosaminidase and 24 h urine protein quantity were decreased(P<0.05) and the glomerular filtration rate was obviously increased(P<0.05) in the treatment group,while only the serum level of uric acid was decreased in the control group(P<0.05) after treatment. There were statistically significant differences on above indexes between the two groups after treatment(P<0.05).Conclusion Uric acid-reducing Decoction combined with allopurinol in the treatment of uric acid nephropathy with syndrome of qi deficiency of spleen and kidney and dampness-heat accumulated in interior can not only significantly decrease the serum level of uric acid,but also improve the glomerular filtration function and renal tubule repair function,and reduce the proteinuria level.更多还原