【摘要】 目的观察何氏桑麻杏贝汤联合西药治疗慢性阻塞性肺疾病急性加重期的临床疗效。方法将60例慢性阻塞性肺疾病急性加重期患者随机分成治疗组和对照组,每组30例。对照组予西医常规治疗,治疗组予何氏桑麻杏贝汤加西医常规治疗。两组疗程均为14天,观察临床疗效,比较咳嗽症状总积分、内毒素鲎测定水平、肺功能及呼吸困难等级(m MRC等级)的变化情况。结果 (1)治疗组、对照组临床总有效率分别为93.3%、66.7%;组间临床疗效比较,治疗组明显优于对照组(P<0.05)。(2)组间治疗后比较,咳嗽症状总积分与FEV1(%)水平差异有统计学意义,治疗组改善程度明显优于对照组(P<0.05)。(3)治疗前后组内比较,两组内毒素鲎测定水平差异均有统计学意义(P<0.05);组间治疗前后差值比较,内毒素鲎测定水平差异有统计学意义,治疗组降低幅度明显大于对照组(P<0.05)。(4)组间治疗后比较,m MRC等级变化差异有统计学意义,治疗组明显优于对照组(P<0.05)。结论何氏桑麻杏贝汤联合西药治疗慢性阻塞性肺疾病急性加重期的疗效满意,可明显改善患者气流受限症状,有效抑制机体急性炎症反应,进而有助于尽快控制病情。更多还原

【Abstract】 Objective To observe the clinical efficacy of He’s Sangma Xingbei Decoction combined with western medicine in the treatment of acute exacerbation of chronic obstructive pulmonary disease（ AECOPD）. Methods 60 AECOPD patients randomly divided into the treatment group and control group,30 cases in each group. The control group was treated with the conventional therapy of western medicine,and the treatment group was treated with He’s Sangma Xingbei Decoction combined with the conventional therapy of western medicine,with a course of 14 days. The clinical efficacy was observed,and the changes on the total score of coughing symptom,level of limulus amebocyte lysate test,pulmonary function indexes and dyspnea grades in modified British Medical Research Council（ m MRC）questionnaire were compared. Results（1）The clinical total effective rates were 93. 33% in the treatment group and 66. 67% in the control group. The clinical efficacy of the treatment group was obviously better than that of the control group（ P<0.05）.（2）After treatment,there were statistically significant differences on the total score of coughing symptom and level of FEV₁（ %） between the two groups,and the improvement in the treatment group was obviously better than that in the control group（ P<0.05）.（3）In both groups,there was statistically significant difference on the level of limulus amebocyte lysate test between treatment before and after（ P<0.05）. For the D-value of level of limulus amebocyte lysate test between treatment before and after,there was statistically significant difference on the Dvalue between the two groups,and the D-value of the treatment group was greater than that of the control group（ P<0.05）.（4）After treatment,there were statistically significant differences on the m MRC grades between the two groups,and the symptom improvement in the treatment group was obviously better than that in the control group（ P<0.05）. Conclusion He’s Sangma Xingbei Decoction combined with western medicine shows good efficacy in the treatment of acute exacerbation of chronic obstructive pulmonary disease,which can obviously improve the symptoms of airflow limitation in patients,effectively inhibit the acute inflammatory response and then help to control the illness as soon as possible.更多还原