【摘要】 目的:探讨宫调音乐疗法对结直肠癌术后化疗患者生存质量及细胞免疫的影响。方法:选取结直肠癌术后脾气亏虚证化疗患者82例,随机分为化疗组和化疗加音乐组(简称"音乐组"),每组各41例。所有患者均给予FOLFOX6或Cape OX方案化疗,音乐组在化疗同时给予宫调音乐疗法,两组治疗周期均为4个化疗周期。比较两组患者脾气亏虚证的中医证候评分,采用欧洲癌症研究与治疗组织的生命质量核心量表(EORTC QLQ-C30V3.0)对患者进行生存质量评价,检测患者外周血中CD2~+、CD3~+、CD4~+T细胞比例。结果:治疗后,两组患者的中医证候总积分均明显升高(P<0.05),其中音乐组患者的证候总积分较化疗组明显降低(P<0.05)。治疗后,两组患者的EORTC QLQ-C30各项功能领域评分和总健康状况评分均明显下降(P<0.05),而音乐组患者的躯体功能、角色功能、情绪功能、总体健康状况评分较化疗组明显升高(P<0.05);两组患者的各项症状领域(包括疲倦、恶心呕吐、失眠、腹泻、经济困难)评分均明显升高(P<0.05),化疗组患者的便秘评分亦显著升高(P<0.05),而音乐组患者的疲倦、恶心呕吐、失眠、便秘、腹泻评分较化疗组明显降低(P<0.05)。治疗后,化疗组患者的CD4~+比率较治疗前降低(P<0.05),音乐组患者的CD2~+、CD3~+、CD4~+T细胞比率较治疗前升高(P<0.05);且音乐组患者的CD2~+、CD3~+、CD4~+T细胞比率较化疗组亦明显升高(P<0.05)。结论:宫调音乐能提高结直肠癌术后化疗患者的生存质量,改善患者的中医证候,其机制可能与促进外周血中CD2~+、CD3~+、CD4~+表达,调控机体的免疫功能相关。更多还原

【Abstract】 Objective: To explore the effects of Gong-tune music therapy on the quality of life and cellular immunity in postoperative chemotherapy patients with colorectal carcinoma. Methods: Eighty-two postoperative chemotherapy patients of colorectal carcinoma with syndrome of spleen-qi deficiency were selected and randomly divided into the chemotherapy group and music combined with chemotherapy group( short for"music group"),41 cases in each group. All the patients received the chemotherapy regimens of FOLFOX6 or Cape OX,and the patients in the music group received Gong-tune music therapy based on chemotherapy. The treatment course of both groups was 4 chemotherapy periods. The Chinese medical syndrome score of spleen-qi deficiency syndrome was compared,the quality of life was evaluated by EORTC QLQ-C30 V3. 0,and the levels of CD2~+,CD3~+and CD4~+T lymphocytes in peripheral blood were detected.Results: After treatment,the Chinese medical syndrome scores of both groups were obviously increased( P<0.05),and the score of the music group was lower than that of the chemotherapy group( P<0.05). After treatment,the scores of all functional items and the general health of EORTC QLQ-C30 in both groups were markedly decreased( P < 0. 05),and the scores of physical function,role function,emotional function and general health in the music group were higher than those in the chemotherapy group( P < 0. 05); the scores of symptomatic items( including fatigue,nausea and vomiting,insomnia,diarrhea and economic difficulty) in both groups were markedly increased( P< 0. 05),the score of constipation in the chemotherapy group was also increased( P < 0. 05),and the scores of fatigue,nausea and vomiting,insomnia,constipation and diarrhea in the music group were lower than those in the chemotherapy group( P<0.05).After treatment,the level of CD4~+in the chemotherapy group was decreased( P < 0. 05),the levels of CD2~+,CD3~+and CD4~+in the music group were increased( P < 0. 05),and the levels of CD2~+,CD3~+and CD4~+in the music group were higher than those in the chemotherapy group( P<0.05). Conclusion: Gong-tune music can enhance the quality of life in the postoperative chemotherapy patients with colorectal carcinoma and improve the Chinese medical syndromes. Its mechanisms may be associated with the promotion of expressions of CD2~+,CD3~+and CD4~+in peripheral blood and the adjustment of immune function.更多还原