【摘要】 创伤性骨关节炎(post-traumatic osteoarthritis,PTOA)与运动医学紧密相关,发病机制复杂、大多难以治愈,一直是临床关注的重点。软骨细胞作为关节软骨中唯一的固有细胞,在创伤性骨关节炎的发病机制和病程进展中占有重要的地位。近年来关于软骨细胞介导骨关节炎的研究大多集中在机制、通路以及潜在治疗靶点的探索上,多方面生物学效应共同作用及促炎和抗炎反应的不平衡可视为PTOA的主要发病机制。本文依据近年来骨关节炎发病机制的研究,对力学改变激活软骨细胞介导PTOA的相关研究成果进行归纳。更多还原

【Abstract】 Post-traumatic osteoarthritis(PTOA)has been drawing great attention clinically because of its tight connections with sports medicine and complicated pathogenesis as well as difficulties to heal.Chondrocyte is the only cell type in articular cartilage,and it plays an important role in the pathogenesis and progression of PTOA.Recent years,researchers mostly focus on the mechanisms,signaling and potential targets to treat osteoarthritis.Combined effects of biomechanics and the imbalance between pro-inflammation and anti-inflammation induce the PTOA eventually.This review would make a summary of the pathogenesis based on the research progress of mechanical alterationactivated chondrocytes-mediated PTOA.更多还原