【摘要】 目的利用乳腺MR影像全自动量化分析法,评估不同月经状态对乳腺纤维腺体组织比(fibrograndular tissue,FGT),背景实质强化容积比(background parenchymal enhancement volume ratio,BPE_V)和程度比(background parenchymal enhancement intensity ratio,BPE_I)的影响。方法从2009年至2012年在复旦大学附属肿瘤医院做乳腺MR检查的14 033名妇女中,随机选出正常乳腺MR影像101例,其中绝经前47例,绝经后54例。绝经前再按月经周期分为:第1周8例,第2至第4周各13例。应用乳腺MR影像全自动量化分析软件测量FGT与增强后早(2 min)、中(4 min)、晚(6 min)3期的BPE_V与BPE_I,并使用Mann-Whitney U检验对绝经前后的FGT,BPE_V和BPE_I进行比较,绝经前各月经周期的比较采用Kruskal-Wallis检验。结果绝经后妇女的FGT,BPE_V与增强中晚期的BPE_I均显著低于绝经前妇女(P<0.05)。BPE_I在绝经前妇女中月经第1周最高,第2周最低(P<0.05)。FGT及BPE_V在月经第1周也最高,但与其他月经周比较差异无统计学意义。结论 FGT、BPE_V和BPE_I在绝经后均显著降低。月经第2周为乳腺MR检查的最佳时间。更多还原

【Abstract】 Objective To evaluate the influence of menopause status on breast fibrograndular tissue(FGT),background parenchymal enhancement volume ratio(BPE_V)and intensity ratio(BPE_I)by breast MR image automatic quantitative analysis. Methods From14 033 consecutive patients who underwent breast MR in our center from~2009 to 2012,we randomly selected 101 normal cases(47 cases of premenopausal and 54 cases of postmenopausal).Premenopausal status was subclassified into four groups(8 cases in the 1 st week and 13 cases in the 2 nd,3 rd and 4 th week,respectively)based on the menstrual cycle.We evaluated FGT,BPE_Vand BPE_Iat early(2 minutes),medium(4 minutes)and late(6 minutes)enhanced time phases of breast MRI for quantitative assessment.The FGT,BPE_Vand BPE_Iin premenopausal and postmenopausal women were compared using the Mann-Whitney U test.Comparison of each menstrual cycle was made using the Kruskal-Wallis test. Results The FGT,BPE_V and middle-late BPE_I of postmenopausal women were significantly lower than that of premenopausal women(P<0.05).The maximum BPE_Iwas in the 1 st week,the minimum in the 2 nd week in premenopausal women(P<0.05).The FGT and BPE_Vin the 1 st week were the highest among the 4 weeks,but there was no significant difference. Conclusions The FGT,BPE_Vand BPE_I were significantly decreased after menopause.The optimal time of breast MR examination is in the 2 nd week of menstrual cycle.更多还原