【摘要】 马兜铃酸肾病(AAN)不仅是我国常见的慢性肾间质性疾病,而且也是巴尔干肾病的致病因素之一。由于涉及的地域及人群广泛,且目前尚无有效治疗方案,相当比例的AAN患者肾功能进行性减退至终末期肾衰竭(ESRD),已成为全球性的公共卫生问题。加强有关AA肾毒性的宣传教育和监督管理,进一步探讨AAN的发病机制,寻找有效干预靶点,不仅对于正确认识和使用中医药,而且对于减少ESRD患病率具有重要的科学和现实意义。更多还原

【Abstract】 Aristolochic acid nephropathy( AAN) is not only a common chronic renal interstitial disease in China,but also one of the pathogenic factors of Balkan endemic nephropathy. Due to the disease involvement of a large geographic area and population,and the lack of effective treatment,a significant proportion of AAN patients progress to end-stage renal disease( ESRD),which has become a global public health problem. Strengthening the publicity,education,supervision,and management of AA nephrotoxicity,further exploring the pathogenesis of AAN,and seeking effective intervention targets have important scientific and practical significance for not only correct understanding and use of Chinese medicine,but also reducing the prevalence of ESRD.更多还原