【摘要】 目的:观察造血干细胞移植(hematopoietic stem cell transplantation,HSCT)后有慢性移植物抗宿主病患者的早、晚期口腔黏膜及牙周改变的临床表现,探讨慢性移植物抗宿主病对口腔状况的影响。方法:收集108例造血干细胞移植后患者,按移植后治疗时间不同分为移植时间小于1年(n=32)和超过1年(n=43) 2组。采用问卷调查、临床检查,收集临床资料,确定罹患口腔慢性移植物抗宿主病患者的基本信息,记录口腔黏膜及牙周病损及严重程度,采用SPSS21.0软件包进行统计学分析。结果:HSCT后出现口腔表征发生率为78.95%,HSCT小于1年组与HSCT超过1年组的轻度症状发生率分别为59.38%和18.60%,差异显著(χ2=11.525,P=0.001);HSCT超过1年的苔藓样反应与HSCT小于1年的发生率分别为60.47%和31.25%,差异有统计学意义(χ2=6.274,P=0.012);浅、中度牙周袋患者检出率分别为49.38%和40.74%;可视牙菌斑、牙结石、牙龈出血检出率分别为62.96%、64.20%和50.62%。结论:HSCT后黏膜及牙周改变的发生率较高,早期口腔黏膜慢性移植物抗宿主病轻度症状明显,晚期口腔表现则以苔藓样反应为主。更多还原

【Abstract】 PURPOSE: The aim of this study was to investigate the severity and status of oral mucosa and periodontal status in early and late stage after receiving hematopoietic stem cell transplantation(HSCT). METHODS: This study enrolled patients submitted to hematopoietic stem cell transplantation. Through a survey questionnaire, clinical examination, we collected clinical data from 108 HSCT recipients and divided them into 2 groups: transplantation time less than 1 year and more than 1 year. The oral mucosal and periodontal status were recorded and statistically analyzed with SPSS 21.0 software package. RESULTS: The incidence of oral features after HSCT was 78.95%. The incidence of mild symptoms with HSCT less than 1 year(n=32) and HSCT more than 1 year(n=43) was 59.38% and 18.60%, respectively.There was significant difference between the two groups(χ2=11.525, P =0.001).The percent of lichenoid/hyperkeratotic plaques was 31.25% and 60.47%, respectively. The lichenoid/hyperkeratotic plaques were significantly different between the two groups(χ2=6.274, P =0.012). The detection rate of shallow and moderate pockets was 49.38% and 40.74%,respectively. Visual plaque, calculus and bleeding on probing were 62.96%, 64.20% and 50.62%, respectively.CONCLUSIONS: The incidence of periodontal and mucosal lesions after HSCT is high. The mild symptoms of oral graft versus host disease in early stage are identified obviously, mainly like lichenoid/hyperkeratotic plaques in late stage.更多还原