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代谢型谷氨酸受体5与N-甲基-D-天冬氨酸受体的关系及其在疾病中的作用
Relationship between metabotropic glutamate receptor 5 and N-methyl-D-aspartate receptor and their roles in diseases
【摘要】 代谢型谷氨酸受体5(metabotropic glutamate receptor 5,mGluR5)和N-甲基-D-天冬氨酸受体(N-methyl-D-aspartate receptor,NMDAR)分别属于代谢型和离子型谷氨酸受体家族。近年来,这2类谷氨酸受体在神经及精神类疾病中的研究较受关注。该文主要就2类谷氨酸受体之间的联系及其与疾病关系的最新研究进展进行回顾与总结。
【Abstract】 Metabotropic glutamate receptor 5(m Glu R5) and N-methyl-D-aspartate receptor(NMDAR) belongs to metabotropic and ionotropic glutamate receptor family,respectively.In recent years,a lot of attention has been paid to these two types of glutamate receptors in the field of neuroscience and psychiatry.This article mainly summarized the research progress of the relationship between these two kinds of receptors and the influence of their relationship on different diseases.
【关键词】 代谢型谷氨酸受体5;
N-甲基-D-天冬氨酸受体;
SH3和多锚蛋白重复结构域3;
Homer蛋白;
【Key words】 metabotropic glutamate receptor 5; N-methyl-D-aspartate receptor; SH3 and multiple ankyrin repeat domains 3; Homer protein;
【Key words】 metabotropic glutamate receptor 5; N-methyl-D-aspartate receptor; SH3 and multiple ankyrin repeat domains 3; Homer protein;
【基金】 国家自然科学基金(81671083);上海市科学技术委员会自然基金面上项目(17ZR1421100)~~
- 【文献出处】 上海交通大学学报(医学版) ,Journal of Shanghai Jiaotong University(Medical Science) , 编辑部邮箱 ,2018年07期
- 【分类号】R363
- 【被引频次】12
- 【下载频次】280