【摘要】 目的观察喉癌组织p21、SLC7A11表达变化,并探讨其在喉癌发生、发展中的作用。方法采用免疫组化SP法检测327例份喉癌组织(喉癌组)和62例份声带息肉组织(对照组) p21、SLC7A11表达。分析喉癌组织p21、SLC7A11表达与患者临床病理特征的关系。采用Kaplan-Meier法分析喉癌组织p21、SLC7 A11表达与患者预后和复发的关系。结果喉癌组p21、SLC7 A11阳性表达率均高于对照组(χ~2分别为8. 53、8. 56,P均<0. 05)。喉癌组织SLC7 A11阳性表达与肿瘤临床分期有关(P <0. 05)。喉癌组织p21阳性表达与肿瘤临床分期及淋巴结转移有关(P均<0. 05)。喉癌组织SLC7A11阳性表达/p21阴性表达与患者术后复发有关(P <0. 01),与患者生存期无明显相关性(P> 0. 05)。SLC7A11阳性表达/p21阴性表达者术后复发时间明显短于SLC7A11阴性表达/p21阴性表达者、SLC7A11阴性表达/p21阳性表达者、SLC7A11阳性表达/p21阳性表达者(χ~2分别为9. 344、8. 304、5. 924,P均<0. 05),但生存时间与SLC7A11阴性表达/p21阴性表达者、SLC7 A11阴性表达/p21阳性表达者、SLC7 A11阳性表达/p21阳性表达者比较差异无统计学意义(χ~2=4. 592,P> 0. 05)。结论喉癌组织SLC7 A11高表达、p21低表达,二者表达变化与患者术后复发有关,而与术后生存时间关系不大。更多还原

【Abstract】 Objective To observe the expression of p21 and SLC7 A11 in the laryngeal carcinoma,and to explore its role in the occurrence and progression of laryngeal carcinoma. Methods The relative expression of p21 and SLC7 A11 in327 cases of laryngeal carcinomas tissues( laryngeal carcinoma group) and 62 cases of vocal polyps( control group) was detected by immunohistochemical SP method. The relationship between the expression and the clinicopathological features of laryngeal carcinoma was analyzed. Kaplan-meier method was used to analyze the relationship between p21 and SLC7 A11 expression and prognosis and recurrence of patients with laryngeal carcinoma. Results The positive expression levels of p21 and SLC7 A11 were higher in the laryngeal carcinoma group than in the control group( χ~2= 8. 53,8. 56,both P <0. 05). High expression of SLC7 A11 was associated with high clinical stage of laryngeal cancer( P < 0. 05). Low expression of p21 was associated with high clinical stage and lymph node metastasis in the laryngeal carcinoma( all P < 0. 05).SLC7 A11 +/p21-expression was related to the recurrence of laryngeal cancer( P < 0. 01) and was not related to the survival of patients with laryngeal cancer( P > 0. 05). Patients with SLC7 A11 +/p21-had longer recurrence time than that of patients with SLC7 A11-/p21-,SLC7 A11-/p21 +,or SLC7 A11 +/p21 + χ~2= 9. 344,8. 304,and 5. 924,all P <0. 05,but no statistically significant difference was found in the overall survival time( χ~2= 4. 592,P > 0. 05). Conclusion The high expression of SLC7 A11 and the low expression of p21 in the laryngeal carcinoma are related to the disease progression and postoperative recurrence,but have no relationship with postoperative survival.更多还原