【摘要】 目的研究医用器械消毒液对器械的消毒效果及其有关性能。方法采用理化分析、载体定量和定性杀菌试验和动物毒性试验方法进行试验观察。结果该器械消毒液原液有效氯含量为4.90 g/L,经37℃恒温存放90 d后,有效氯含量下降率平均为7.76%。用有效氯含量为2 000 mg/L的器械消毒液浸泡作用5 min,对载体上枯草杆菌黑色变种芽孢的平均杀灭对数值为4.27;作用20 min,对载体上枯草杆菌黑色变种芽孢可达到完全杀灭。有效氯含量为4 000 mg/L的器械消毒液,作用20 min,对污染于止血钳关节部位上枯草杆菌黑色变种芽孢可达到完全杀灭。连续使用7 d的器械消毒液杀菌效果基本不下降。有机物对器械消毒液杀菌效果有轻度影响。用有效氯含量为4 900 mg/L的器械消毒液浸泡72 h,对不锈钢、碳钢、铜、铝基本无腐蚀。该器械消毒液小鼠经口LD50>10 000 mg/kg(体质量);对小鼠骨髓嗜多染红细胞微核试验结果阴性。结论该器械消毒液性能稳定,毒性低,对金属基本无腐蚀;在常规使用浓度下对载体上细菌芽孢具有较好的杀灭效果。更多还原

【Abstract】 Objective To study the efficacy of medical instrument disinfection solution for instruments and its related properties. Methods Physicochemical analytic method,carrier quantitative and qualitative germicidal test and animal toxicity test were carried out. Results The available chlorine content in stock solution of the instrument disinfection solution was 4. 90 g/L and decreased by 7. 76% in average after storing at constant 37℃ temperature for 90 days. The average killing logarithm value of Bacillus subtilis var. niger spores on carrier immersed in the instrument disinfection solution containing available chlorine 2 000 mg/L for 5 min was 4. 27 and the spores of B. subtilis var. niger on carrier exposed for 20 min could be killed completely. The spores of B. subtilis var. niger on joints of hemostatic forceps exposed to disinfection solution containing available chlorine 4 000 mg/L for 20 min could be killed completely. The four metal materials including stainless steel,carbon steel,copper and aluminum immersed in the stock solution of the disinfection solution for 72 h were essentially not corroded.The mouse oral LD50 of the instrument disinfection solution was > 10 000 mg/kg( bw) and its mouse bore marrow polychromatic erythrocyte micronucleus test was negative. Conclusion The instrument disinfection solution is stable,low toxic,essentially not corrosive to metals. Its solution of conventional concentration has good efficacy in killing bacterial spores on carriers.更多还原