【摘要】 目的:观察隔姜灸联合盐酸坦索罗辛胶囊治疗CP/CPPS患者的治疗效果及可能的机制。方法:将CP/CPPS患者360例随机分为实验组120例,对照组120例及空白对照组120例。实验组予口服盐酸坦索罗辛胶囊,每次0.2mg,每日1次,并行隔姜灸治疗,每日1次。对照组仅口服盐酸坦索罗辛胶囊,每次0.2mg,每日1次。空白对照组不给于任何关于CP/CPPS相关治疗处理。三组均治疗30天。观察治疗后各组患者临床症状的改善情况、EPS中WBC阳性例数、EPS中TNF-α、IL-1β、卵磷脂小体含量变化及外周血中CD3~+、CD4~+、CD8~+、CD4~+CD25~+、CD4~+CD25~+Foxp3~+、TGF-β1的表达水平。结果:治疗后,实验组NIH-CPSI总体评分明显低于对照组及空白对照组;实验组EPS中卵磷脂小体含量明显高于对照组及空白对照组;实验组EPS中炎性因子TNF-α、IL-1β水平明显低于对照组及空白对照组;治疗组EPS中WBC阳性总例数由治疗前的86例减少为治疗后的20例,明显优于对照组及空白对照组;治疗后实验组及对照组患者外周血CD3~+、CD4~+、CD8~+、CD4~+CD25~+、CD4~+CD25~+Foxp3~+、TGF-β1含量均明显提高,但治疗后实验组水平均明显高于对照组及空白对照组。结论:隔姜灸可显著改善CP/CPPS患者的临床症状,其治疗作用可能与隔姜灸提高患者的免疫功能有关。更多还原

【Abstract】 Objective: To study the therapeutical effect and mechanism of ginger-partitioned moxibustion combined with tamsulosin on CP/CPPS patients. Methods: We randomly divided 360 the type CP/CPPS patients into experimental,controlled and blank controlled groups,two groups were treated with oral administration of the tamsulosin for 30 days（ 0. 2 mg,1/d）,and the experimental group was treated with ginger-partitioned moxibustion at the same time. After treatment,we observed the improvements of clinical symptoms and the changes of thelevels of CD₃⁺,CD₄⁺,CD₈⁺,CD₄⁺CD₂₅⁺,CD₄⁺CD₂₅⁺Foxp₃⁺,transforming growth factor（ TGF）-β1 in the three groups. Results: After treatment,the total efficiency in the experimental group was higher than that of the controlled group and blank controlled group; the NIH-CPSI scores,TNF-α,IL-1βlevels in EPS from the experimental group were significantly lower than those in the controlled group and blank controlled group; the WBC positive total number of cases in the experimental group from 86 cases before treatment reduced to 26 cases,were significantly higher than that in the controlled group and the blank control group; the levels of seminal plasma lecithin body in the experimental group were higher than that in the controlled group and blank controlled group. At last,the levels of CD₃⁺,CD₄⁺,CD₈⁺,CD₄⁺CD₂₅⁺,CD₄⁺CD₂₅⁺Foxp₃⁺,TGF-β1 from the experimental group were much higher than those in the cotrolled group and blank controlled group. Conclusion: Ginger-partitioned moxibustion can improve clinical symptoms of CP/CPPS patients,these results may be associated with the improving of patients’ immune function.更多还原