【摘要】 【目的】调查乳腺癌患者中医体质情况,探讨乳腺癌临床病理特征与中医体质类型的相关性,以期为乳腺癌的中医个性化治疗提供参考。【方法】采用横断面调查方法,以调查问卷的方式收集2014年12月至2017年7月在广东省中医院乳腺科治疗的300例乳腺癌患者相关信息,判定中医体质类型,观察乳腺癌患者主要中医体质类型与临床病理特征、转移情况等的关系。【结果】(1)本研究共发出调查问卷300份,回收合格问卷271份,合格问卷回收率为90.3%。(2)271例乳腺癌患者的主要中医体质类型依次为:平和质(21.4%)、气郁质(18.8%)、阳虚质(18.1%)、气虚质(11.8%)、血瘀质(8.1%)。(3)上述各主要中医体质类型乳腺癌患者的年龄、原发病灶组织学类型、雌激素受体(ER)和孕激素受体(PR)表达状态、表皮生长因子受体2(HER2)表达状态、细胞增殖核抗原(Ki67)表达状态及分子分型的构成比较,差异均无统计学意义(P>0.05);但临床分期和转移部位比较,差异有统计学意义(P<0.01),其中与是否发生脑转移比较,差异无统计学意义(P>0.05),与是否发生肺转移、肝转移、骨转移比较,差异有统计学意义(P<0.05或P<0.01)。【结论】乳腺癌患者中医主要体质类型为平和质、气郁质、阳虚质、气虚质、血瘀质,乳腺癌的发生发展可能与中医体质类型有一定的关系。更多还原

【Abstract】 Objective To investigate the distribution of traditional Chinese medicine(TCM)constitution types inbreast cancer patients and to explore the correlation of the clinicopathological characteristics of breast cancer withthe TCM constitution types, thus to provide a reference for the personalized treatment of breast cancer withChinese medicine. Methods A cross-sectional survey was applied. The questionnaire was used to collect the data of300 cases of breast cancer admitted in Guangdong Provincial Hospital of Traditional Chinese Medicine fromDecember of 2014 to July of 2017. After then,the TCM constitution types of the patients were identified,and thecorrelation of constitution types with clinicopathological characteristics and metastasis was investigated. Results(1)A total of 271 questionnaires were obtained after 300 questionnaires were released,with the effective response ratebeing 90.3%.(2)The main TCM constitution types of the 271 patients were harmony constitution(21.4%),Qi-stagnation constitution(18.8%),yang-deficiency constitution(18.1%),Qi-deficiency constitution(11.8%),and blood-stasis constitution(8.1%).(3)There was no statistical significance in comparison of the main TCMconstitution types with the age groups, primary tumor histological types, estrogen receptor and progesteronereceptor expression, human epidermal growth factor receptor 2(HER2)expression, proliferating cell nuclearantigen Ki67 expression and its molecular typing(P > 0.05). In comparison of the main TCM constitution typeswith the clinical staging and metastasis types, the differences were statistically significant(P<0.01). Incomparison of the main TCM constitution types with brain metastases,the difference was no statistically significant(P > 0.05),while the differences were statistically significant(P < 0.05 or P < 0.01)as compared with lungmetastasis,liver metastasis and bone metastasis. Conclusion The main TCM constitution types of breast cancerpatients are harmony constitution, Qi-stagnation constitution, yang-deficiency constitution, Qi-deficiencyconstitution,and blood-stasis constitution. The occurrence and development of breast cancer may be correlatedwith the TCM constitution types.更多还原