【摘要】 目的:观察化瘀通络汤联合常规疗法治疗大脑中动脉狭窄或闭塞型脑梗死的临床疗效。方法:选取120例大脑中动脉狭窄或闭塞型脑梗死患者,随机分为对照组及治疗组各6 0例,治疗过程中2组各脱落1例。2组均给予常规治疗,治疗组在此基础上加用化瘀通络汤。对比2组治疗前后美国介入和治疗神经放射学会/介入放射学会(ASITN/SIR)侧支血流分级评分、美国国立卫生研究院卒中量表(NIHSS)及改良Ra n kin量表(MRS)评分,记录不良反应发生情况。结果:治疗后,2组ASITN/SIR侧支血流分级评分均较治疗前改善(P<0.05),治疗组ASITN/SIR侧支血流分级评分改善情况优于对照组(P<0.05)。治疗14、28、9 0天,2组NIHSS评分均逐渐下降(P<0.05)。治疗14天,2组NIHSS评分比较,差异无统计学意义(P>0.05)。治疗28、9 0天,治疗组NIHSS评分均低于对照组(P<0.05)。治疗后,MRS评分为0、1、2分(预后良好)占比治疗组为56.0%,对照组为3 4.0%,均较治疗前增高(P<0.05);治疗组MRS评分为0、1、2分患者占比高于对照组(P<0.05)。结论:化瘀通络汤联合常规疗法治疗大脑中动脉狭窄或闭塞型脑梗死,能有效改善患者的侧支循环及神经功能缺损情况。更多还原

【Abstract】 Objective: To observe the clinical effect of Huayu Tongluo tang combined with routine therapy for cerebral infarction due to middle cerebral artery stenosis or occlusion. Methods: Selected 120 cases of patients with cerebral infarction due to middle cerebral artery stenosis or occlusion, and divided them into the control group and the treatment group randomly, 60 cases in each group. One case dropped out from both groups respectively during treatment. Both groups received the routine treatment, while the treatment group additionally received Huayu Tongluo tang. Compared the collateral flow classification scores of American society of intervention and therapeutic neuroradiology/society of interventional radiology(ASITN/SIR), scores of the national institutes of health stroke scale(NIHSS) and the scores of modified Rankin scale(MRS) in both groups before and after treatment, and recorded the occurrence of adverse reactions. Results:After treatment,the collateral flow classification scores of ASITN/SIR in both groups were improved when comparing with those before treatment(P < 0.05), the improvements of the collateral flow classification scores of ASITN/SIR in the treatment group were better than those in the control group(P < 0.05). On the 14 th,28 th and 90 th day,the scores of NIHSS in both groups were gradually decreased(P < 0.05). On the 14 thday, there was no significant difference being found in the scores of NIHSS in both groups(P > 0.05). On the 28 thand 90 thday,the scores of NIHSS in the treatment group were all lower than those in the control group(P < 0.05). After treatment,the scores of MRS being 0,1 and 2(good prognosis) accounted for 56.0% in the treatment group and 34.0% in the control group,which were higher than those before treatment(P < 0.05);the number of patients with the scores of MRS being 0, 1 and 2 in the treatment group was larger than that in the control group(P < 0.05). Conclusion: Huayu Tongluo tang combined with routine therapy for cerebral infarction due to middle cerebral artery stenosis or occlusion can effective improve the collateral circulation and the damage degree of neurological function of patients.更多还原