【摘要】 目的探讨外周血中T淋巴细胞亚群、免疫球蛋白E(IgE)、C反应蛋白(CRP)和血清降钙素原(PCT)水平改变在儿童哮喘临床治疗中的意义。方法选择84例哮喘患儿作为哮喘组,60例健康儿童作为对照组,测定并比较外周血T淋巴细胞亚群和IgE水平。哮喘组患儿根据是否合并感染,测定并比较血中CRP及PCT含量。结果哮喘组CD3~+、CD4~+和CD19~+细胞均高于对照组,CD8~+低于对照组,CD4~+/CD8~+比例高于对照组,差异均有统计学意义(P<0.05);哮喘组Th2细胞和IgE高于对照组,Th1/Th2低于对照组,差异有统计学意义(P<0.05)。两组Th1比较差异无统计学意义(P>0.05);哮喘合并细菌感染组的患儿CRP和PCT阳性率高于其他两组哮喘患儿,哮喘合并病毒感染组患儿CRP和PCT阳性率高于单纯哮喘组,差异有统计学意义(P<0.05)。结论外周血T淋巴细胞亚群和IgE水平可作为反应哮喘患儿疾病状态指标,结合检测CRP和PCT可判断哮喘患儿是否合并感染,在治疗过程中起辅助治疗及评定药物效果的作用。更多还原

【Abstract】 Objective To investigate the clinical significance of level changing of peripheral blood T lymphocyte subsets,immunoglobulin E(IgE),C-reactive protein(CRP)and procalciton(PCT)in children with asthma. Methods 84 children with asthma were selected as asthma group and 60 healthy children were selected as control group. Peripheral blood T lymphocyte subsets and serum IgE level were measured. The serum CRP and PCT levels of the asthma group were measured and compared between children with or without concurrent infection. Results The level of CD3~+,CD4~+,CD19~+ and the rate of CD4~+to CD8~+T cells in asthma group were significantly higher than those in control group,but the level of CD8~+T cells was lower than that of the control group(P<0.05). The levels of Th2 and serum IgE were higher than those of the control group and Th1/Th2 level was lower than that in control group(P<0.05). There was no significant difference of the level of Th1 between the two groups(P>0.05). The positive rates of CRP and PCT for diagnosing bacterial infection were significantly higher than the other two groups. The positive rates of CRP and PCT of children with asthma combining viral infection were higher than children only with asthma,and the difference was statistically significant(P<0.05).Conclusion Peripheral blood T lymphocyte subsets and Ig E levels could serve as indicators of disease state of children with asthma,together with the detection of PCT and CRP to diagnose whether combining infection could assist to evaluate the curative effect of drugs and therapy.更多还原