【摘要】 目的探讨冠状动脉粥样硬化性心脏病(冠心病)合并甲状腺功能异常的临床特点和血脂代谢分析。方法选取2010年1月~2016年1月于青海省人民医院内分泌科收治的冠心病患者102例,根据甲状腺功能状况,分为甲状腺功能减退组(甲减组)20例,亚临床甲状腺功能减退组(亚临床甲减组)26例及甲状腺功能正常组(正常组)56例。分析三组患者临床特点以及血脂代谢情况。结果甲状腺功能正常组同甲减组、亚临床甲减组在三酰甘油(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)及B型尿钠肽(BNP)水平上差异具有统计学意义(P<0.05);甲减组患者游离三碘甲状腺原氨酸(FT3)及游离甲状腺素(FT4)水平低于正常组,促甲状腺激素(TSH)水平明显高于正常组,差异均有统计学意义(P<0.05);亚临床甲减组FT3、FT4水平与正常组相当,但TSH水平高于正常组,差异均有统计学意义(P<0.05)。甲减组未见单支病变者,3支病变的比例显著高于亚临床甲减组及正常组,差异有统计学意义(P<0.05)。结论冠心病患者很容易发生甲减以及亚临床甲减,其可能导致患者发生较为严重的血脂代谢异常,因此临床上需加强对冠心病患者的甲状腺功能检查,从而使患者的治疗更为科学合理。更多还原

【Abstract】 Objective To explore the clinical features and related factors of coronary heart disease with abnormal thyroid function. Methods We selected 102 patients with coronary heart disease from January 2010 to January 2016 from department of endocrinology of Qinghai provincial people’s hospital, and analyzed the clinical characteristics and related factors of patients with coronary heart disease with abnormal thyroid function. Results102 coronary heart disease patients, including 20 cases of hypothyroidism, 26 cases of subclinical hypothyroidism, and 56 cases of normal thyroid function in patients with coronary heart disease(CHD). The difference between thyroid function normal group and hypothyroidism group, subclinical hypothyroidism group in TG, TC, LDL-C and BNP was statistically significant(P<0.05). The levels of FT3 and FT4 in hypothyroidism group were lower than those in the normal group, and the TSH level was significantly higher than that of the normal group, and the difference was significant(P<0.05). The level of FT3 and FT4 in subclinical hypothyroidism group was similar to that of normal group, but the TSH level was higher than that of normal group, and the difference was significant(P<0.05). The proportion of 3 lesions in low FT3 group was significantly higher than that of normal FT3 group(P<0.05). There was no single lesion in the lower FT3 group. The proportion of 3 lesions was significantly higher than the normal FT3 group(P<0.05). Conclusion In patients with coronary heart disease is likely to happen hypothyroidism and subclinical hypothyroidism, it could lead to dyslipidemia in patients with serious. Therefore, the clinic need to strengthen the thyroid function examination of patients with coronary heart disease, so that the patient’s treatment is more scientific and reasonable.更多还原