【摘要】 [目的]研究cis-4-甲氧基环己基-1-氨基甲酸的合成新方法。[方法]以cis-8-甲氧基-1,3-二氮杂螺[4,5]癸-2,4-二酮(简称LC-酰胺)为起始原料,在氢氧化钡碱性条件下水解得到目标产物。[结果] cis-4-甲氧基环己基-1-氨基甲酸的顺式含量达98%以上,收率达96%。[结论]该合成新方法具有含量高、收率高、操作简便,能有效避免副产氯化钠盐的生成。更多还原

【Abstract】 [Aims] A new synthetic method for cis-4-methoxycyclohexane-1-amino-carboxylic acid was studied.[Methods] The target product was obtained by hydrolysis of starting material cis-8-methoxy 1,3-diaza-spiro[4,5]decane2,4-dione under alkaline conditions of barium hydroxide. [Results] The content of cis-4-methoxycyclohexane-1-amino-carboxylic acid reach above 98%, and the yield reach 96%. [Conclusions] The new process has the advantages of simple operation, high content, high yield, and can effectively avoid the formation of by-product sodium chloride.更多还原