【摘要】 针对将功能性电刺激应用于贲门失弛缓症及术后反流的治疗需要,设计了一种基于ZigBee通信的自启动食管起搏系统.系统采用ZigBee通信技术和双相压控恒流源技术进行设计,实现了植入式刺激器和外部遥控设备之间的双向通信,保证脉冲参数实时可调.同时,系统前端安装弯曲传感器,采集吞咽信号,自动启动体内刺激器.此外,系统利用MSP430F149超低功耗模式和ZigBee定时唤醒技术实现了植入式设备的低功耗要求.在不同的通信距离下对系统进行测试,证明了ZigBee通信的可行性.对5名受试者进行吞咽信号采集与处理实验,结果显示,系统可以100%检测到受试者吞咽引起的电压变化.利用高精度示波器和万用表对系统生成的刺激脉冲的强度、频率、脉宽性能指标进行测试,数据分析结果表明,实际测量值与理论值相对误差均小于2.08%.利用食管起搏器对家兔食管进行单点电刺激,结果显示一定幅值的刺激脉冲能引起食管的有效收缩,验证了设计原理的正确性和系统的可行性.更多还原

【Abstract】 Based on the idea of applying functional electrical stimulation( FES) in the treatment of achalasia and postoperative gastroesophageal reflux,a self-starting esophagus pacemaker system based on ZigBee communication is designed in this paper. ZigBee communication and bi-phase voltage controlled constant-current sources are adopted in the system,which can realize the bi-directional ZigBee communication between the implanted stimulator and the extracorporeal controller,and can ensure the real-time control of the stimulation. Meanwhile,the bend sensor is applied at the front-end of the system to acquire swallowing signal and realize self-starting. Besides,the employment of low-power mode of MSP430 F149 and the synchronous wake-up technology of ZigBee meet the low-power requirement of the system. The feasibility of ZigBee communication in this system is proved by a series of tests with different distances.Five volunteers attended in the swallowing signal acquisition and processing experiment. The results indicate that the voltage variation caused by the volunteers were 100% detected. The intensity,frequency and pulse width of the stimulation pulse generated by the core stimulator were measured with a high precision oscilloscope. The data indicates that the relative error between measured values and theoretical values is less than 2. 08%. The esophagus pacemaker system was applied to the esophagus of rabbits,and the result reveals that a certain stimulation results in the contraction of the esophagus muscle,verifying the correctness of the design theory and the reasonability of the system.更多还原