【摘要】 目的:探究贵州遵义市中老年男性血清雄激素水平与血脂代谢的关系。方法:采用分层整群抽样方法在遵义市抽取437例年龄≥40岁的男性行问卷调查和体格检查,采集空腹肘静脉血样标本检测血清总睾酮(TT)、性激素结合球蛋白(SHBG)、黄体生成素(LH)、总胆固醇(TCH)、甘油三脂(TG)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL),计算游离睾酮(FT)、游离睾酮指数(FTI)和睾酮分泌指数(TSI)。结果:中年组SHBG、LH、HDL和LDL均低于老年组,FT、FTI、TSI高于老年组(P均<0.05)。TT和SHBG与TG、TCH、HDL和LDL呈负相关,FT与TCH呈正相关,FTI与TG、TCH和LDL呈正相关,TSI与TCH、HDL和LDL呈正相关,LH与TG、TCH和LDL呈负相关(P均<0.05)。多元线性回归分析显示TT和SHBG与TG、TCH、HDL、LDL仍呈负相关;LH与TCH、HDL和LDL呈负相关(P均<0.05)。结论:中老年男性血清TT、SHBG和LH降低有增加患高TC血症和高LDL血症风险,TT和SHBG降低有增加患高TG血症风险,而TT、SHBG和LH升高有增加患低HDL血症风险。更多还原

【Abstract】 Objective:To investigate the relationship of the levels of serum androgens with lipid metabolism in middle-aged and elderly men in Zunyi,Guizhou.Methods:Using the stratified cluster sampling method,we conducted a questionnaire investigation and physical examinations among 437 men in Zunyi City.We divided the subjects into a middle-aged(40-64[53.20±7.41]years,n=269)and an elderly group(≥65[70.63±4.66]years,n=168)and collected fasting elbow venous blood samples from them for measuring the levels of total testosterone(TT),sex hormone-binding globulin(SHBG),luteinizing hormone(LH),total cholesterol(TCH),triglyceride(TG),high-density lipoprotein(HDL),low-density lipoprotein(LDL),calculated free testosterone(cFT),free testosterone index(FTI),and testosterone secretion index(TSI).Results:Compared with the elderly group,the middle-aged males showed significantly lower SHBG,LH,HDL and LDL,and higher cFT,FTI,TSI,TG and TCH(all P<0.05).TT and SHBG were negatively correlated with TG,TCH,HDL and LDL,while cFT was positively correlated with TCH,and so was FTI with TG,TCH with LDL,and TSI with TCH,HDL and LDL(all P<0.05),but LH was negatively correlated with TG,TCH and LDL(all P<0.05).Multivariate linear regression analysis showed that TT and SHBG were negatively correlated with TG,TCH,HDL and LDL,and so was LH with TCH,HDL and LDL(all P<0.05).Conclusion:In the middle-aged and elderly men in Zunyi,low concentrations of TT,SHBG and LH were associated with the increased risk of high-TCH and-LDL dyslipidemia,low concentrations of TT and SHBG with that of high-TG dyslipidemia,while high concentrations of TT,SHBG and LH with that of lowHDL dyslipidemia.更多还原