【摘要】 目的探讨hs-CRP、IL-6、IL-18、TNF-α和TGF-β1在Ig A肾病中的临床应用价值。方法选取2010年6月至2013年11月肾穿刺活检确诊的Ig A肾病患者71例,根据病理Lee氏分级的结果将Ig A肾病组分为3个亚组,轻度组(Ⅰ级+Ⅱ级)32例,中度组(Ⅲ级)17例,重度组(Ⅳ级+Ⅴ级)22例;同时选取35例健康对照。检测各组血清Scr、Urea、CysC和尿UTP水平及血清炎症因子hs-CRP、IL-6、IL-18、TNF-α和TGF-β1水平,并比较各炎症因子与Scr、Urea、CysC和尿UTP的相关性。结果 Ig A肾病患者各组血清hs-CRP、IL-6、IL-18、TNF-α和TGF-β1水平逐渐增高,与健康对照组有显著性差异(P<0.05);随着疾病进展,重度组各炎症因子水平与轻度组和中度组比较有显著性差异(P<0.05);各炎症因子与Scr、Urea、CysC和尿UTP呈正相关(P<0.05)。结论炎症介质可以监测肾损伤程度,炎症损伤与Ig A肾病进展有密切关系。更多还原

【Abstract】 To investigate clinical significance of hs-CRP, IL-6, IL-18, TNF-α and TGF-β1 in patients withIg A nephropathy, total of 71 patients diagnosed by renal biopsy from June 2010 to November 2013 wereprospectively observed. According to Lee’s histological classification, all patients with nephropathy were dividedinto three groups: mild group(32 cases, gradeⅠ+Ⅱ), moderate group(17 cases, grade Ⅲ), and severe group(22 cases, grade Ⅳ+Ⅴ), while 35 healthy adults were recruited as healthy control. Then we detected the serumlevels of Scr, Urea, CysC, hs-CRP, IL-6, IL-18, TNF-α, TGF-β1 and UTP(urine total 24 hours protein), andanalyzed the association of related inflammatory cytokines with Scr, Urea, CysC, and UTP. Data showed that thelevels of hs-CRP, IL-6, IL-18, TNF-α and TGF-β1 in Ig A nephropathy increased accordingly with thepathological grade increase and higher than those of healthy control group(P<0.05); the levels of hs-CRP, IL-6,IL-18, TNF-α and TGF-β1 in severe group were higher than those in mild group and moderate group(P<0.05).Furthermore, the levels of hs-CRP, IL-6, IL-18, TNF-α and TGF-β1 were positively correlated with the level ofScr, Urea, CysC and UTP(P<0.05). In conclusion, inflammatory cytokines can reflect pathological lesions in Ig Anephropathy patients, and has positively correlated with disease development.更多还原