【摘要】 目的探索体重指数(BMI)对正常人群的成年男性血清前列腺特异性抗原(PSA)水平的影响。方法收集2015年01月至2016年12月在西安交通大学第一附属医院体检中心进行健康体检者的资料,筛选所有年龄、身高、体重、血清总PSA水平数据完整的成年男性体检者。计算BMI并根据BMI中国标准将研究对象分为偏瘦(BMI<18.5kg/m~2)、正常(BMI 18.5~23.9kg/m~2)、偏胖(BMI 24.0~27.9kg/m~2)、肥胖(BMI≥28kg/m~2)4组;按照年龄分为18~29、30~39、40~49、50~59、60~69、70~79、≥80岁7组,方差分析分别比较各BMI组内PSA水平的差异。结果共收集资料完整者共15 830例,平均年龄(50.87±14.07)岁;平均BMI(25.19±3.11)kg/m~2;平均PSA(1.18±1.04)ng/mL。血清PSA在18~29、30~39、40~49岁组基本保持不变,之后随年龄增长而增加。偏瘦、正常、偏胖及肥胖组PSA分别为(1.42±1.29)、(1.28±1.13)、(1.14±0.98)及(1.03±0.95)μg/L,PSA水平随BMI增加而显著降低。在30~39和40~49岁年龄组内,总PSA水平随BMI升高而降低最为显著。结论血清总PSA在50岁后随年龄增长增加明显;血清总PSA随着BMI的增加而降低,这一趋势在30~39和40~49岁年龄组最为显著。更多还原

【Abstract】 Objective To investigate the relationship between body mass index(BMI)and serum prostate-specific antigen(PSA)level in adult males.Methods The health examination data of adult males were collected during Jan.2015 and Dec.2016,including the age,height,weight,and serum PSA level.The subjects were categorized as underweight(BMI<18.5 kg/m~2),normal(BMI 18.5-23.9 kg/m~2),overweight(BMI 24.0-27.9 kg/m~2),and obese(BMI≥28.0 kg/m~2).The subjects were divided into 7 groups based on the age:18-29,30-39,40-49,50-59,60-69,70-79 and ≥80 year old groups.The PSA levels were stratified by BMI category for statistical analysis.Results A total of 15,830 adult males were included,mean age(50.87±14.07)years,mean BMI(25.19±3.11)kg/m~2,and mean PSA(1.18±1.04)μg/L.The PSA level was stable before the subjects were 50 years old,and then increased with age.The PSA in the underweight,normal,overweight,and obese groups were(1.42±1.29),(1.28±1.13),(1.14±0.98)and(1.03±0.95)μg/L,respectively,which decreased significantly with the increase of BMI,and this negative correlation was more significant in the 30-39 and 40~49 year old groups.Conclusion The PSA level increases with age after the subjects are 50 years.There is a negative correlation between BMI and PSA,especially in the 30-39 and 40-49 year old groups.更多还原