【摘要】 报道2例类脂质渐进性坏死(NL)并对国内外相关文献进行复习。例1,女,12岁。双胫前棕黄色萎缩性斑块2年、破溃2个月,病理确诊为NL。患者1合并2型糖尿病、高脂血症、重度肥胖,给予胰岛素降糖、双嘧达莫片,0.1%他克莫司软膏、多磺酸粘多糖乳膏外用等,皮损逐渐好转。例2,女,50岁。左下肢硬性红斑4年、加重2年,病理确诊为NL。患者2合并2型糖尿病,给予雷公藤多苷片、多磺酸粘多糖乳膏等,皮损逐渐好转。更多还原

【Abstract】 Two patients with necrobiosis lipoidica( NL) were reported and related literatures were reviewed in this paper. Patient one was a 12-year-old girl,who presented with brown yellow atrophic plaques on lower extremities for 2 years and ulcerated for 2 months. The biopsy features suggested NL. The patient was accompanied with type 2 diabetes,hyperlipidemia and severe obesity. The lesions subsided gradually after treated with insulin,dipyridamole tablets,topical tacrolimus ointment and mucopolysaccharide polysulfonate cream. Patient two was a 50-year-old female,who presented with erythema on left shin for more than 4 years,aggravated for 2 years. This patient was also accompanied with type 2 diabetes and the biopsy features were also in accordance with NL. The lesions subsided gradually after treated with tripterygium and mucopolysaccharide polysulfonate cream.更多还原