【摘要】 目的观察亚临床甲状腺功能减退(SCH,简称亚临床甲减)对高龄老人颈动脉易损斑块的影响。方法选取80岁以上的老年住院患者118例,其中甲状腺功能正常组78例,亚临床甲减组40例。超声评价颈动脉斑块性质,分析甲状腺功能正常组及亚临床甲减组易损斑块检出率及两组血脂、血糖、尿酸等生化指标,用logistic回归探讨高龄老人易损斑块形成的危险因素。结果亚临床甲减组易损斑块的检出率为52.5%,甲状腺功能正常组易损斑块的检出率为30.8%,亚临床甲减组易损斑块的检出率高于甲状腺功能正常组,差异有统计学意义(χ~2=5.292,P=0.028)。logistic回归分析显示,亚临床甲减、总胆固醇增高与高龄老人易损斑块形成存在相关性(P<0.05)。结论亚临床甲减、总胆固醇水平增高可能影响高龄患者颈动脉易损斑块的形成,应关注高龄老人甲状腺功能及血脂控制。更多还原

【Abstract】 Objective To observe the effect of subclinical hypothyroidism( SCH) on the vulnerable carotid artery plaque in the advanced-ages. Methods This study was performed on 118 elderly patients with age over 80,including 78 cases with normal thyroid function and 40 cases with SCH. Characteristics of carotid plaque of these patients were evaluated by ultrasound. The detection rate of vulnerable carotid artery plaque and the level of blood glucose,lipid,uric acid of the two groups were compared. Logistic regression was used to analyze the risk factors of vulnerable carotid artery plaque. Results The detection rate of vulnerable carotid artery plaque in SCH group was 52. 5%,where as in normal thyroid function groupwas 30. 8%. There was significantly difference between them( χ~2= 5. 292,P = 0. 028). Logistic regression showed that the vulnerable carotid artery plaque was related to significantly subclinical hypothyroidism and total cholesterol in the advanced-ages( P < 0. 05). Conclusion Subclinical hypothyroidism and the increase of total cholesterol are associated with vulnerable carotid artery plaque. Screening of thyroid function and the cotroll of lipid should be focused in the advanced-ages.更多还原