Objective To investigate the clinical characteristics and treatment of hyperkalemia caused by tacrolimus after liver transplantation. Methods Clinical data of one patient diagnosed with hyperkalemia induced by tacrolimus following liver transplantation were collected and retrospectively analyzed. Results The concentration of tacrolimus was elevated after addition of voriconazole,and the risk of hyperkalemia was increased when potassium-sparing diuretics was used. Conclusion Tacrolimus blood concentration,li...