【摘要】 目的研究绝经后骨量减少合并2型糖尿病(T2DM)患者血清骨保护素(OPG)、转化生长因子-β(TGF-β)和白细胞介素-6(IL-6)水平的变化;评估血清OPG、TGF-β和IL-6水平对绝经后骨量减少合并T2DM患者10年骨折风险的影响;分析上述因子在绝经后T2DM患者骨折进展中的作用。方法该回顾性研究共纳入128名绝经后骨量减少患者,其中64名合并T2DM患者(-2.5<T值<-1.0)为实验组,并将64名单纯骨量减少患者(糖代谢正常)设置为对照组;比较两组骨密度(BMD)、血清OPG、TGF-β和IL-6水平;应用骨折风险评估工具对上述研究对象的10年骨折风险进行预测,评估不同血清因子与10年骨折风险的相关性。结果绝经后骨量减少合并T2DM患者的BMD与单纯骨量减少患者的BMD之间没有统计学差异(Z=0.841,P>0.05);绝经后骨量减少合并T2DM患者血清OPG(Z=2.264,P=0.024)、TGF-β(Z=2.836,P=0.005)和IL-6(Z=2.431,P=0.015)水平高于单纯骨量减少患者;两组患者的血清OPG、TGF-β、IL-6水平与10年骨折风险均存在相关性。结论绝经后骨量减少合并T2DM患者的促炎细胞因子和OPG水平高于单纯骨量减少患者,促炎因子TGF-β和IL-6水平的升高对于预测绝经后骨量减少合并T2DM患者的骨折风险具有重要意义。更多还原

【Abstract】 Objective To evaluate the variations of serum OPG, TGF-β and IL-6 levels with bone loss in postmenopausal women with or without type 2 diabetes mellitus(T2 DM), to elucidate the role of serum OPG, TGF-β and IL-6 levels in prediction for 10-year probability of fracture risk, and to explore the impact of serum OPG, TGF-β and IL-6 levels on the progression of type 2 diabetic fracture. Methods This study included 128 postmenopausal women who were diagnosed as osteopenia(areal bone mineral density at spine and hip of all subjects were measured by DXA, patients with T score more than-2.5 and less than-1.0 were diagnosed as osteopenea). They were divided into two groups, T2 DM group and non-T2 DM group.Besides of BMD, all subjects were measured the serum levels of OPG, TGF-β and IL-6. Furthermore, we predicted the 10-year probability of fracture risk in all cohorts by FRAX? and analyzed the correlations of the risk with serum levels of OPG, TGF-β and IL-6 in all subjects. Results There were no significant differences of BMD between the two groups(Z=0.841, P>0.05). However, the serum levels of OPG(Z=2.264, P=0.024), TGF-β(Z=2.836, P=0.005) and IL-6(Z=2.431, P=0.015) in T2 DM group were higher than that in non-T2 DM group. Furthermore, the serum levels of OPG, TGF-β and IL-6 were correlated with the10-year probability of fracture risk in T2 DM group. Conclusion The serum levels of OPG, TGF-β and IL-6 increased in osteopenia patients with T2 DM, suggesting that the increased inflammatory factors could be used as predictors for the 10-year probability of fracture risk in osteopenia patients with T2 DM.更多还原