【摘要】 目的调查浙江省平湖地区城乡人群血浆同型半胱氨酸(homocysteine, Hcy)水平及分布情况,并分析其相关因素。方法 2014年1月至2015年3月,在浙江省平湖市9个镇(街道)采用分层随机抽样法,选取社区体检人群623例进行问卷调查。调查内容包括一般情况(包括性别、年龄、BMI、既往病史等)、饮食习惯(包括高盐、高脂、辛辣饮食等)及实验室检查(包括Hcy及总胆固醇、LDL-C、肌酐等)情况。结果本组人群高Hcy血症患病率为31.78%(198/623),男性患病率(19.26%,120/623)明显高于女性(12.52%,78/623)。623例社区体检人群Hcy水平4.46～28.77(18.29±3.64)μmol/L,其中男性Hcy水平明显高于女性(t=3.98,P <0.05)。不同年龄段(40岁以下、40～59岁、60～79岁、80岁及以上)Hcy水平的差异有统计学意义(F=4.07,P <0.05),且Hcy水平与年龄呈正相关(r=0.996,P <0.05)。不同年龄段男性Hcy水平均高于女性(P <0.05)。血清Hcy水平与年龄、性别、BMI及总胆固醇、LDL-C、血肌酐水平、吸烟、高盐或高脂饮食相关(P <0.05或0.01)。结论平湖地区人群中高Hcy血症的发生率较高,并且存在性别及年龄差异,不良生活习惯如吸烟、高盐、高脂饮食是其危险因素。更多还原

【Abstract】 Objective To investigate the levels and distribution of plasma homocysteine(Hcy) in urban and rural populations in Pinghu of Zhejiang Province and their related factors. Methods From January 2014 to March 2015, useing stratified random sampling and questionnaire survey, 623 subjects were select from 9 towns(streets) in Pinghu of Zhejiang Province. The survey included general conditions(including gender, age, BMI, past medical history, etc.), eating habits(including high-salt, high-fat, spicy diet, etc.) and laboratory tests(including Hcy and total cholesterol, LDL-C, creatinine, etc.). ResultsThe prevalence of hyperhomocysteinemia was 31.78%(198/623), and the prevalence of males(19.26%, 120/623) was significantly higher than that of females(12.52%, 78/623). The Hcy level of 623 subjects was 4.46 ～ 28.77(18.29±3.64) μmol/L, and the Hcy level of male was significantly higher than that of female(t=3.98, P<0.05). The difference of Hcy levels in different age groups(40 years old, 40 ～ 59 years old, 60 ～ 79 years old, 80 years old and above) was statistically significant(F=4.07, P<0.05), and Hcy level was positively correlated with age(r=0.996, P<0.05). The Hcy level of males in different age groups was higher than that of females(P<0.05). Serum Hcy levels were associated with age, gender, BMI and total cholesterol, LDL-C, serum creatinine levels, smoking, high salt or high fat diet(P<0.05 or 0.01). Conclusion The incidence of hyperhomocysteinemia is higher in Pinghu, and there are differences on gender and age. Negative lifestyle habits such as smoking, high salt and high fat diet are risk factors.更多还原