【摘要】 炎症小体是胞浆多蛋白复合物,在病原体入侵及其他危险信号刺激时进行组装,对抗病原微生物及内源性危险信号,保障宿主健康。然而,炎症小体异常激活可引起慢性炎症甚至诱发肿瘤。目前,针对NLRP3炎症小体的研究最为深入,NLRP3炎症小体与人体多种疾病的发生发展密切相关。本文主要对NLRP3炎症小体与结肠炎及其相关肠癌的关系以及基于炎症小体的相关防治进展进行综述。更多还原

【Abstract】 Inflammasomes are cytosolic multi-protein platforms and assembled in response to invading pathogens and other danger signals.They guard the host robustly from the assault of microbial pathogens and endogenous danger signals.However,abnormal activation of NLRP3 inflammasome can cause chronic inflammation and even oncogenesis.NLRP3 inflammasome is by far the most thoroughly studied.It has been widely implicated in the development and progression of various chronic diseases.This review mainly introduces the role of NLRP3 inflammasome in inflammarory bowel disease and colitis-assosicated cancer,relevant prevention,and treatment measurement based on inflammasomes.更多还原