【摘要】 利尿剂是治疗各种病因导致的体液容量超负荷的基本药物。本文简单回顾了人类抗击体液潴留的历史,重点介绍了目前主要用于治疗体液潴留的药品——不同利尿剂的研发历史,开发思路及作用机理。新的排水利尿剂对于传统排钠利尿剂是很好的互补,遵循权威部门颁布的指南可帮助临床医生合理使用不同类型利尿剂。更多还原

【Abstract】 Diuretics are a cornerstone in the treatment of volume overload with different pathological origin. This article briefly reviewed the history of human’s way of removing excess water, especial introduced the process of discovering natriuretics and aquaretics. To discover a new drug successfully, research teams need continued efforts and a combined knowledge of both biology and chemistry. The newly developed aquaretics had a good complementary effect with conventional saluretics. Adhering to credible guidelines could help to optimize the use of different classes of diuretics.更多还原