【摘要】 [目的]综合评价食物不耐受血清特异性IgG抗体检测结果的饮食指导对溃疡性结肠炎疗效的影响,量化该类饮食指导的效果。[方法]检索中外数据库中公开发表的基于食物不耐受血清特异性IgG抗体检测结果的饮食指导在溃疡性结肠炎患者中应用的文献资料。采用Cochrane Handbook(5.1.0)对文献质量进行评价,RevMan5.3软件对资料进行Meta分析。[结果]最终纳入文献7篇,共计519例患者。Meta分析结果显示,基于食物不耐受检测血清特异性IgG结果的饮食指导临床有效率(RR=1.41,95%CI:1.16、1.72,P<0.05)优于常规饮食指导,疾病活动指数(WMD=-1.24,95%CI:-1.66、-0.83,P<0.01)低于对照组,差异均有统计学意义。[结论]基于食物不耐受血清特异性IgG抗体检测结果的饮食指导,可以提高溃疡性结肠炎患者的临床疗效。但是由于纳入文献数量及质量限制,可能影响本次Meta分析结果的可靠性和论证强度。更多还原

【Abstract】 [Objective]To evaluate the efficacy of clinical improvements of ulcerative colitis by dietary interventions based on the results of food specific IgG antibody testing,and to quantify the effect of diet interventions.[Methods]Dietary interventions for UC patients based on the results of food specific IgG antibody testing were retrieved from Chinese and foreign databases,and some other related papers were manually checked.The quality of included studies were assessed according to Cochrane Handbook,then the Meta-analysis was performed by RevMan 5.3 software.[Results]At last,7 articles including 519 patients were involved.Meta-analysis showed that the clinical efficacy was significantly higher in the intervention group than the control group(RR= 1.41;95%CI:1.16,1.72;P<0.05).Disease activity index(WMD=-1.24;95%CI:-1.66,-0.83;P<0.01)was significantly lower than control group.[Conclusion]The dietary in-terventions based on the results of food specific IgG antibody testing can improve the efficacy of clinical efficacy and reduce disease activity index.However due to the quantity and quality of the included literature,it may affect the reliability of the meta-analysis results.更多还原