【摘要】 目的 探讨氟比洛芬酯对老年手术患者血清白细胞介素-6、白细胞介素-10水平的影响。方法 将80例老年拟行手术患者按随机数字表法分为两组,每组40例,麻醉前研究组予以缓慢静脉注射氟比洛芬酯微球载体注射液(1 mg·kg^-1),对照组予以同等剂量生理盐水,观察两组手术时间、尿量、术中出血量、术中输液量及输血量,采用疼痛视觉模拟评分法评定两组术后12 h、24 h疼痛程度,检测两组麻醉前及术后2 h、24 h血清白细胞介素-6、白细胞介素-10水平的变化。结果 两组手术时间、尿量、术中出血量、术中输液量及输血量比较差异无统计学意义（P>0.05）。术后12h、24h研究组疼痛视觉模拟评分显著低于对照组（P<0.05）。术后2h、24 h两组血清白细胞介素-6水平显著高于麻醉前,术后24 h显著低于术后2 h（P<0.01）,研究组术后2 h、24 h血清白细胞介素-6水平显著低于对照组（P<0.01）;术后2 h、24 h两组血清白细胞介素-10水平显著高于麻醉前（P<0.01）,术后24 h显著高于术后2 h（P<0.01）,研究组术后2 h、24 h血清白细胞介素-10水平显著高于对照组（P<0.01）。结论 对老年手术患者麻醉前予以氟比洛芬酯微球载体注射液缓慢静脉注射,具有改善患者术后疼痛程度及抗炎作用,能抑制术后促炎症因子白细胞介素-6的释放,促进抗炎因子白细胞介素-10的释放。更多还原

【Abstract】 Objective To investigate the effect of flurbiprofen axetil on serum IL-6, IL-10 levels in elder surgery patients. Methods 80 cases of elder surgery patients were randomly divided into two groups, 40 cases in each group. Before anesthesia, the observation group was given slow intravenous injection of flurbiprofen axetil liposomal prostaglandin(1 mg · kg^-1), and the control group was given the same dose of saline solution, observe the operation time, urine volume, intraoperative blood loss, intraoperative transfusion volume and blood transfusion volume of the two groups. VAS was used to evaluate the pain degree of the two groups at 12 h,24 h after the operation,detect the level changes of serum IL-6,IL-10 of the two groups before anesthesia and at 2 h, 24 h after the operation. Results There was no statistic significance in the operation time, urine volume, intraoperative blood loss, intraoperative transfusion volume and blood transfusion volume between the two groups（P>0. 05）. At 12 h, 24 h after the operation, VAS score of the observation group was significantly lower than that in the control group（P<0. 05）. At 2 h,24 h after the operation, serum IL-6 levels of the two groups were significantly higher than those before anesthesia, and the levels at 24 h after the operation were significantly lower than those at 2 h after the operation（P<0. 01）, serum IL-6 levels in the observation group at 2 h, 24 h after the operation were significantly lower than those in the control group（P<0. 01）; at 2 h,24 h after the operation, serum IL-10 levels of the two groups were significantly higher than those before anesthesia（P<0. 01）, and the levels at 24 h after the operation were significantly higher than those at 2 h after the operation（P<0. 01）, serum IL-10 levels in the observation group at 2 h, 24 h after the operation were significantly higher than those in the control group（P<0. 01）. Conclusion The application of slow intravenous injection of flurbiprofen axetil liposomal prostaglandin in elder surgery patients can improve postoperative pain degree and anti-inflammatory action,it can inhibit the release of proinflammatory factor IL-6 and promote the release of anti-inflammatory cytokine IL-10.更多还原