Objective To explore the levels of p21~(Waf1/cip1) and p27~(Kip1) in functional pituitary adenomas,and analyse the relationship between the levels of p21~(Waf1/cip1) and p27~(Kip1) and clinical features. Method Tissue microarray technology was performed among 6 cases with normal pituitaries, 36 invasive pituitary adenomas and 58 non-invasive pituitary adenomas.Immunohistochemistry experiment was used to detect the protein levels of p21~(Waf1/cip1) and p27~(Kip1). The clinicopathologic data of 94 patients wa...
【基金】
北京市自然科学基金(7162035);
北京市卫计委高层次人才计划(2015-3-040)
【更新日期】
2018-05-11
【分类号】
R736.4
【正文快照】
作者单位:100050北京,北京市神经外科研究所Conclusion In functional pituitary adenomas,the levels of p21Waf1/cip1and p27Kip1are negativelycorrelated with the invasion,and promoter methylation influences the level of p27Kip1.垂体腺瘤是最常见的神经系统肿瘤之一
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