【摘要】 目的:检测慢性特发性荨麻疹(CIU)患者血清中维生素D水平变化并评估其临床意义。方法:采用酶联免疫吸附法(ELISA)测定126例CIU患者(CIU组)及88例健康人(对照组)外周血血清中25-羟基维生素D[25-(OH)D]水平,并检测2组受试者血清中总IgE水平。结果:CIU组外周血血清中25-(OH)D水平[(39.18±1.63)nmol/L],较对照组[(65.91±1.92)nmol/L]明显降低(P<0.01)。CIU组外周血血清中总IgE水平[(151.31±18.92)g/L],较对照组[(25.76±9.45)g/L]明显增高(P<0.01)。CIU患者血清中25-(OH)D水平与总IgE水平呈负相关(r=-0.787,P<0.01),与荨麻疹活动评分呈负相关(r=-0.686,P<0.01)。结论:CIU组血清中维生素D水平下降;维生素D缺乏可能与CIU的发病相关。更多还原

【Abstract】 Objective: To measure the serum levels of 25-(OH)D in patients with chronic idiopathic urticaria(CIU) and to determine the relationship between vitamin D levels and patients’ susceptibility to CIU. Methods: The serum levels of 25-hydroxyvitamin D[25-(OH)D] and total IgE levels were measured in 126 patients with CIU and 88 healthy controls,using enzyme-linked immunosorbent assay(ELISA). Results: Serum 25-(OH)D levels decreased significantly in the CIU group compared with those in the controls(39.18±1.63 nmol/L vs. 65.91±1.92 nmol/L, P<0.01). In contrast, total serum IgE levels increased significantly in the CIU group compared with those in the controls(151.31±18.92 g/L vs. 25.76±9.45 g/L, P<0.01).Serum 25-(OH)D levels were negatively correlated with total serum IgE levels in CIU patients(r=-0.787,P<0.01), and negatively correlated with urticaria activity scores(r=-0.686, P<0.01). Conclusions: Patients with CIU have significantly lower levels of vitamin D. Vitamin D deficiency may be related to the occurrence of CIU.更多还原