【摘要】 目的探讨预注不同剂量顺式阿曲库铵对其起效时间的影响。方法选择2014年11月至2015年4月南京医科大学第一附属医院择期手术全麻患者80例,男41例,女39例,年龄18~60岁,随机均分为四组,每组20例。对照组(C组)预注生理盐水3 ml,C1组、C2组、C3组分别预注顺式阿曲库铵15、30、50μg/kg,1min后再分别静脉注射剩余剂量顺式阿曲库铵0.15、0.135、0.12、0.10mg/kg,麻醉诱导顺序静脉注射咪达唑仑0.05mg/kg、芬太尼5.0μg/kg、依托咪酯0.3mg/kg,采用四个成串刺激(TOF)监测,记录静脉注射剩余插管剂量后T4/T1=0的时间,记录呼吸困难、荨麻疹、心律失常等不良反应的情况。结果C3组起效时间为(114.2±14.1)s,明显短于C2组(136.3±28.1)s、C1组(164.6±26.9)s和C组(165.9±10.8)s(P<0.01)。四组患者均未见呼吸困难、荨麻疹、心律失常等不良反应。结论与顺式阿曲库铵15和30μg/kg比较,顺式阿曲库铵50μg/kg预注能明显缩短肌松起效时间。更多还原

【Abstract】 Objective To investigate different priming dose of cisatracurium effect on the onset time.Methods In the First Affiliated Hospital of Nanjing Medical University from November 2014 to April 2015,eighty adult patients(male 41 cases,female 39 cases age from 18 to 60.)scheduled for selective surgery,were randomly divided into four groups,20 in each.Control group(group C)priming with 3 ml saline,group C1 priming with cisatracurium 15μg/kg,group C2 priming with cisatracurium 30μg/kg and group C3 priming with cisatracurium 50μg/kg,1 minutes after the priming injection,each group respectively received the left over intubation dose of cisatracurium 0.15,0.135,0.12,0.10 mg/kg,followed by anesthesia induction of midazolam 0.05 mg/kg,fentanyl 5.0μg/kg,etomidate 0.3 mg/kg.Neuromuscular block was monitored using train of four stimulation mode.The time when T4/T1=0 after the left over intubation dose of cisatracurium injection and adverse reaction were recorded.Results The onset time in group C3(114.2±14.1)s was significantly less than that in group C2(136.3±28.1)s,group C1(164.6±26.9)s and group C(165.9±10.8)s(P<0.01).No adverse reaction of dyspnea, urticaria, arrhythmia occurred after priming injection of cisatracurium in all the four groups.Conclusion Priming dose of 50μg/mg cisatracurium can significantly shorten the onset time compared to the priming dose of 15μg/mg and 30μg/mg.更多还原