Chronic rhinosinusitis(CRS)is a Common disease of otorhinolaryngology head and neck surgery,manifested as nasal-sinus mucosal chronic inflammation.However,the pathogenesis of CRS is not clear.There are studies found that microRNA(miRNA)involved in CRS gene regulation.In this review,we summarizes the expression of miRNAs in CRS,with the in-depth study of the role of miRNAs in CRS,and will further elucidates the pathogenesis of CRS.