Utilization of negative checkpoint regulators( NCRs) for immunotherapy has garnered significant interest of oral head and neck tumor research. Compared to chemotherapy,the anti-NCRs targeted drugs are more effective and less harmful with the demonstration of clinical trials. However,with the research of tumor resistance mechanism becoming more and more intensive,myriad tumor resistance cases have appeared for targeted drugs. Therefore,more and more emphasis is focused on combination therapy in order to redu...
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