【摘要】 目的探讨女性腺性膀胱炎中细胞角蛋白7、20(CK7、CK20)的表达及临床意义。方法对20例女性膀胱移行细胞癌(TCC)组织、30例女性腺性膀胱炎组织、20例正常膀胱移行上皮组织采用免疫组织化学Envision二步法进行检测。结果 CK7的表达在女性腺性膀胱炎与膀胱癌之间有统计学差异(χ~2=5.36;P<0.05),与正常膀胱组织之间无统计学差异(χ~2=1.09;P>0.10),但是其在腺性膀胱炎中表达率(60.00%)较正常膀胱组织(45.00%)高。CK20的表达在腺性膀胱炎和膀胱癌之间有统计学差异(χ~2=7.41;P<0.01),与正常膀胱组织之间无统计学差异(χ~2=1.63;P>0.10);腺性膀胱炎的CK20表达率(53.33%)明显高于正常膀胱组织(35.00%)。结论女性腺性膀胱炎转变为膀胱移行细胞癌倾向性较低,是具有一定恶变趋向的良性病变。更多还原

【Abstract】 Objective To investigate the expression and clinical significance of cytokeratin 7,20( CK7,CK20) in female cystitis glandularis. Methods Twenty cases of transitional cell carcinoma of the bladder( TCC),thirty cases of cystitis glandularis and twenty cases of normal urinary bladder transitional epithelium were examined using Envision immunohistochemical method.Results There was statistically significant difference in the expression of CK7 between female cystitis glandularis and bladder cancer( χ~2= 5. 36; P < 0. 05),but there was no significant difference in CK7 expression between normal bladder tissues( χ~2= 1.09; P>0.10) The expression of CK7 in cystitis glandularis( 60.00%) was higher than that in normal bladder tissue( 45.00%). CK20 expressions in cystitis and bladder cancer were significantly different( χ~2= 7.41; P<0.01),but there was no significant difference between normal bladder tissues( χ~2= 1. 63; P > 0. 10) The expression of CK20 in cystitis( 53. 33%) was significantly higher than that of normal bladder tissues( 35. 00%). Conclusion Female cystitis glandularis is a benign lesion that is prone to malignant transformation but is unlikely to turn into bladder transitional cell carcinoma.更多还原