【摘要】 目的探讨影响2型糖尿病患者糖类抗原(CA)199水平的危险因素。方法 2016年9月至2017年9月269例住院2型糖尿病患者根据CA199水平按4分位法分为4组,A组中CA199≤Q1,B组中Q1<CA199≤Q2,C组中Q2<CA199≤Q3,D组中Q3<CA199≤Q4。收集所有患者年龄、身高、体质量、收缩压、舒张压、空腹血糖、空腹C肽、糖化血红蛋白(HbA1c)、丙氨酸氨基转移酶(ALT)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿素氮、肌酐、血尿酸、进食100g馒头后的餐后2h血糖、餐后2hC肽、糖尿病病程等资料。结果 4组患者年龄、BMI、舒张压、ALT、尿素氮、肌酐、空腹血糖、餐后2h血糖、空腹C肽、餐后2hC肽、糖尿病病程、HDL-C比较,差异无统计学意义(P>0.05)。4组患者腰围、收缩压、LDL-C、TC、TG、HbA1c比较,差异有统计学意义(P<0.05)。CA199与TC、TG、LDLC、HbA1c呈显著正相关(P<0.05)。HbA1c、TC、TG、LDL-C是影响CA199的独立危险因素(P<0.05)。结论 2型糖尿病患者的糖脂代谢紊乱可能是影响CA199水平的主要因素。更多还原

【Abstract】 Objective To explore the risk factors of carbohydrate antigen(CA)199 in patients with type 2 diabetes mellitus.Methods A total of 269 patients diagnosed with type 2 diabetes were divided into four groups,such as group A CA199≤Q1,group B Q1<CA199≤Q2,group C Q2<CA199≤Q3,group D Q3<CA199≤Q4.The data of heights,body mass indexes(BMI),waist circumference,systolic and diastolic pressure,fasting blood glucose,fasting C-peptide,hemoglobin A1c(HbA1c),alanine aminotransferase(ALT),total cholesterol(TC),triacylglycerol(TG),high-density lipoprotein cholesterol(HDL-C),low density lipoprotein cholesterol(LDL-C),blood urea nitrogen,creatinine,uric acid,blood glucose and C-peptide after eating100 g steamed bread 2 h,duration of diabetes were collected and analyzed in the four groups.Results Age,BMI,diastolic blood pressure,ALT,blood urea nitrogen,creatinine,uric acid,fasting blood glucose,blood glucose and C-peptide after eating 100 g steamed bread 2 h,fasting C-peptide,duration of diabetes,HDL-C had no significant differences among the four groups(P>0.05).Waist circumference,systolic pressure,LDL-C,TC,TG,HbA1chad significant differences among the four groups(P<0.05).There were positive correlations between CA199 and TC,TG,LDL-C,HbA1c(P<0.05).HbA1c,TC,TG,LDL-C were independent risk factors for CA199.Conclusion Glucose-lipid metabolism disorder was the risk factors of CA199 in patients with type 2 diabetes.更多还原