【摘要】 目的研究类风湿关节炎(RA)患者血清及关节液中免疫球蛋白(Ig)E的水平及其临床意义。方法 87例RA患者纳入RA组,88例骨关节炎(OA)患者纳入OA组,检测2组患者血清和关节液中IgE水平并进行比较。按IgE是否升高将RA患者进一步分为IgE升高组和IgE正常组,对2组患者的关节炎程度和关节外表现进行评估和比较。结果与OA组相比,RA组中有49例患者血清IgE升高,RA组患者血清IgE水平也高于OA组,差异有统计学意义(P=0.000 1)。RA组患者关节液中的IgE也明显高于OA组(P=0.027)。在RA患者中,IgE升高组和IgE正常组人群的肿胀和压痛关节数、红细胞沉降率、C反应蛋白及关节外表现差异无统计学意义(P>0.05)。结论 RA患者体内血清和关节液中IgE水平普遍升高,但IgE的升高并不会导致关节炎更活跃或出现更多的关节外表现。更多还原

【Abstract】 Objective To determine the level of immunoglobulin(Ig)E in serum and synovial fluid,and explore its relationship with clinical parameters in patients with rheumatoid arthritis(RA).Methods A total of87 RA patients were recruited into RA group,and 88 osteoarthritis(OA)patients were selected in control group.The level of IgE in serum and synovial fluid were determined and statistical analyzed.The RA patients were divided into two groups further according to their IgE levels,including IgE elevated group and IgE normal group.The inflammation extent of arthritis and numbers of patients with extra-articular manifestations were compared between the two groups.Results Compared with OA group,there was 49 patients in RA group whose serum IgE elevated,and the mean level of serum IgE in RA group was also higher than that in OA group,the difference was statistically significant(P=0.000 1).The mean IgE level in synovial fluid of RA patients was also significantly higher than that of OA patients(P=0.027).However,comparisons of swollen joints,tender joints,erythrocyte sedimentation rate,C reactive protein and numbers of patients with extra-articular manifestations between IgE elevated group and IgE normal group did not show statistically significant difference(P>0.05).Conclusion Elevation of IgE in both serum and synovial fluid are found in most RA patients,but elevation of IgE doesn′t related to more active arthritis or more extra-articular manifestations.更多还原