【摘要】 目的观察左西孟旦对充血性心力衰竭患者血浆氨基末端脑钠肽前体(NT-pro BNP)及左室射血分数(LVEF)的影响。方法选取我院心内科2015年6月—2017年6月收治的50例充血性心力衰竭患者,随机分为对照组和观察组,每组25例患者。对照组给予常规抗心衰药物治疗,观察组在常规抗心衰药物的基础上加用左西孟旦治疗。观察两组治疗前后血浆NT-pro BNP水平、左室射血分数(LVEF)的差异变化及治疗的总有效率。结果比较两组患者疗效,观察组用药后治疗心衰的有效率为92.0%,高于对照组(64.0%),差异有统计学意义(P<0.05)。在心功能指标上,血浆NT-pro BNP水平、左室射血分数(LVEF)观察组优于对照组,差异有统计学意义(P<0.05)。结论左西孟旦对充血性心力衰竭患者的疗效较好,能改善患者的心脏收缩功能。更多还原

【Abstract】 Objective To observe the effect of Levosimendin on LVEF and plasma NT-pro BNP in patients with congestive heart failure. Methods From Jun 2015 to Jun 2017, 50 patients in our hospital with congestive heart failure were randomly divided into two groups, 25 cases each, according to hospitalized order. The control group underwent routine anti heart failure treatment; patients in the observation group were used Levosimendan. And then observe the changes of plasma levels of NT-pro BNP, and LVEF value of difference between the two groups before and after treatment, after treatment the total effective rate were compared and analyzed. Results After treatment, the effective rate of chronic congestive heart failure of the observation group was 92.0%, apparently higher than the control group(64.0%), t the difference was statistically significant(P<0.05). In cardiac function, plasma NT-pro BNP level and left ventricular ejection fraction(LVEF) in observation group were better than those in control group, the difference was statistically significant(P<0.05). Conclusion Levosimendan is effective in patients with congestive heart failure and can significantly improve the cardiac contractility.更多还原