【摘要】 目的:探讨脑卒中高危人群早期颈动脉粥样硬化(ECAS)与血脂异常之间的关系。方法:2015年10月至2016年4月在扬州地区选取社区人群中≥40岁常驻居民为调查对象。通过脑卒中危险因素评估进一步确定脑卒中高危人群,进行统一的血液生化检测及颈动脉超声检查,分析血脂异常对ECAS的影响。结果:(1)994例(男性497)调查对象平均年龄63.21±9.84岁,甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)水平升高及高密度脂蛋白胆固醇(HDL-C)水平降低的百分比分别为40.0%、11.5%、15.1%、9.5%;ECAS的患病率为48.5%;(2)ECAS组高TC百分比高于正常组(14.0%vs 9.3%,P=0.023);高TG、高LDL-C、低HDL-C百分比组间比较无统计学差异;(3)在校正了相关混杂因素后,高TC发生ECAS的优势比是TC正常的1.8倍,而TG、LDL-C及HDL-C与ECAS无统计学上的关联。结论:脑卒中高危人群中TC升高与早期颈动脉粥样硬化独立相关。更多还原

【Abstract】 Objective:To explore correlation between early carotid artery atherosclerosis(ECAS)and dyslipidemia in a population with high-risk of stroke. Methods:A community-based population aged 40 years or older were sampled between Oct. 2015 to Apr.2016 in Yangzhou. Subjects with high-risk of stroke were selected by appraisal of risk factors and then given with blood tests and carotid artery ultrasonography. The effect of dyslipidemia on ECAS was analyzed. Results:(1)The average age of 944 subjects,out of which497 were male,was 63.21 ± 9.84 years old. The proportion of elevated levels of TG,TC,LDL-C and reduced levels of HDL-C were 40.0%,11.5%,15.1%,9.5% respectively. The prevalence of ECAS was 48.5%.(2)The group of ECAS had a significantly higher proportion of elevated levels of TC in comparison with the normal carotid artery group(14.0% vs 9.3%,P=0.023),whereas there were not significant differences involving the proportion of elevated levels of TG,LDL-C and reduced levels of HDL-C between the two groups.(3)After adjustments for relevant potential confounders,elevated TC was still significantly associated with ECAS(OR=1.8),whereas TG、LDL-C and HDL-C were not significantly associated with ECAS. Conclusions:Elevated TC correlated independently with ECAS in a community-based population with high-risk of stroke.更多还原