【摘要】 目的了解美沙酮维持治疗患者退出风险及影响因素。方法收集2006—2016年全省10个设区市19个美沙酮维持治疗门诊入组收治的7 493例海洛因成瘾患者治疗信息,对其人口学特征、治疗前吸毒状况、治疗后服药特征及退出治疗影响因素进行分析。结果 7 493例患者参加治疗时平均吸毒(9.64±4.66)年,注射吸毒占77.82%。2 328例(31.07%)患者治疗过程中至少退出1次并再次入组治疗,1年退出率为26.50%,3年退出率为49.40%,5年退出率为65.60%。Cox回归分析结果显示,南京市、汉族、曾经戒过毒、较高治疗剂量患者门诊治疗退出风险较低。结论美沙酮维持治疗门诊应加强对患者的综合干预及激励机制,鼓励患者坚持治疗。更多还原

【Abstract】 Objective To analyze risks and influential factors among patients dropped out from methadone treatment in Jiangsu province.Methods Medication information of 7 493 herorin addicts undertaking methadone treatment from 19 methadone treatment clinics were collected from network reports in 10 cities from 2006 to 2016.Demographic characteristics,heroin abuse information before entering treatment,medication characteristics after entering treatment and influential factors of dropping out treatment were analyzed.Results The average duration of heroin abuse before entering clinics was 9.64±4.66 years among 7 493 subjects,the injection drug use accounted for 77.82%.2 328 patients(31.07%)dropped out at least once and re-entered the treatment group.The 1-year quit rate was 26.50%,the 3-year quit rate was 49.40%,and the 5-year dropout rate was 65.60%.Cox regression analysis showed that patients in Nanjing,of Han ethnicity,with drug rehabilitation treatment history or higher dosage of treatment had lower dropout risks from outpatient clinics.Conclusion Methadone treatment clinics should reinforce comprehensive intervention and to set up incentive mechanics in order to encourage patients to persist in treatment.更多还原