【摘要】 目的:研究盐酸赛庚啶的晶型.方法:运用自然结晶和快速结晶方法制备盐酸赛庚啶的晶型,经X射线衍射分析法(PXRD)、差示扫描热分析法(DSC)、热重分析(TG-DTA)等方法对盐酸赛庚啶的多种晶型进行表征.结果:通过调节溶剂和结晶方式得到盐酸赛庚啶的4种晶型,经检测发现盐酸赛庚啶溶解于热的甲醇溶液自然结晶得到晶型Ⅰ,快速结晶得到晶型Ⅱ;当溶剂采用无水乙醇时得到晶型Ⅲ和Ⅳ.结论:Ⅰ~Ⅳ型盐酸赛庚啶的理化性质存在明显差异,最终以甲醇为溶剂,快速结晶制备出了新晶形Ⅱ,晶形Ⅱ熔点最高、融化吸收热量大,具有较好的稳定性,并且晶型纯度高.更多还原

【Abstract】 Objective:To study the polymorphism of cyproheptadine hydrochloride. Methods: The crystalline forms of cyproheptadine hydrochloride were prepared by natural crystallization and rapid crystallization. The various crystal forms of cyproheptadine hydrochloride were characterized by X-ray diffraction, differential scanning calorimetry and thermogravimetry. Results: Cyproheptadine was dissolved in hot methanol solution for natural crystallization to obtain Form Ⅰ, rapid crystallization to obtain Form Ⅱ, in anhydrous ethanol to obtain Form Ⅲ and Ⅳ. Conclusion : The physicochemical properties of Ⅰ~ Ⅳ cyproheptadine were significantly different from each other. Crystal form Ⅱ showed the lowest melting point and the water content conformed to pharmacopoeia standards.更多还原