【摘要】 目的:探讨应用脑栓通胶囊联合多奈哌齐治疗轻中度阿尔茨海默病的疗效观察。方法:选取阿尔茨海默病患者80例为研究对象,采用双盲对照研究,将患者随机分为治疗组和对照组,每组40例。对照组单用多奈哌齐,治疗组给予脑栓通联合多奈哌齐,两组均接受12个月的治疗,治疗期间密切关注病情,比较治疗前后两组患者MMSE、ADL及双侧大脑中动脉的血流速度(VM)和搏动指数(PI)等指标的变化情况,探讨治疗效果。结果:在治疗之后,两组患者的MMSE、VM评分均有所提高,ADL、PI评分均有所下降,与治疗之前比较,差异有统计学意义(P<0.05);且治疗之后的治疗组患者MMSE、VM评分明显高于对照组,ADL、PI评分明显低于对照组,差异有统计学意义(P<0.05)。结论:应用脑栓通胶囊联合多奈哌齐治疗轻中度阿尔茨海默病,获得较好的治疗效果,值得进一步推广应用。更多还原

【Abstract】 Objective To investigate the efficacy of Naoshuantong capsule combined with donepezil in the treatment of mild to moderate Alzheimer’s disease. Method 80 cases of Alzheimer’s patients were selected as the research object,they were randomly divided into treatment group and control group by a double blind control study,each group of 40 peoples. The control group: with donepezil,the treatment group: Naoshuantong combined with donepezil,two groups were treated for 12 months,during the treatment,pay close attention to the disease. The changes of MMSE and ADL and blood flow velocity( VM) and pulsatility index( PI)in two groups of patients before and after treatment were compared,and the therapeutic effect was discussed. Results After treatment,two groups of patients with MMSE、VM scores were increased,ADL、PI scores were decreased,compared with before treatment,the difference was statistically significant( P < 0. 05); And the treatment group of patients after treatment MMSE、VM scores significantly higher than the control group,ADL、PI scores significantly lower than the control group,the difference was statistically significant( P < 0. 05). Conclusion Treatment of mild and moderate Alzheimer’ s disease with Naoshuantong combined with donepezil,get better treatment effect and be worthy of further popularization and application.更多还原