【摘要】 慢性阻塞性肺疾病(COPD)是一种在全球范围内呈高发趋势的肺部慢性炎症性疾病。随着研究的深入,人们逐渐认识到COPD亦具有自身免疫性疾病的特征,但目前对于COPD中获得性免疫的启动机制仍不明确。气道的慢性中性粒细胞炎症是COPD的一个显著特征。研究发现,中性粒细胞在感染状态下可形成一种主要由DNA构成的网状物质——中性粒细胞外诱捕网(NETs),它除了发挥直接的抗感染效应之外,大量的NETs形成还可造成组织损伤,在一些自身免疫性疾病中,NETs甚至能启动获得性免疫应答。文章综述近年来NETs在COPD免疫发病机制中的研究进展及其作为COPD抗炎靶点的可能性,为今后COPD的抗炎治疗提供新的思路。更多还原

【Abstract】 Chronic obstructive pulmonary disease(COPD) is a prevalent chronic inflammatory disease of the lung in the worldwide.With the deeper development of the study,people gradually realized that COPD also with the characteristics of autoimmune diseases.However,the initiation mechanism of acquired immunity in COPD is still unclear.Chronic neutrophilic inflammation of the airways is a distinct feature of COPD.The latest research shows that neutrophils can form a reticular substance composed of DNA in the infected state-NETs,which can not only give full play to the anti infection effect,but also cause tissue damage.In some autoimmune diseases,it can even initiate the acquired immune responses.This paper will briefly review the recent advances of NETs in the pathogenesis of COPD and its potential role as an anti-inflammatory target for COPD,so as to provide new ideas for the anti-inflammatory treatment of COPD in the future.更多还原