【摘要】 色素上皮衍生因子(PEDF)是具有多种生物学活性的内源性糖蛋白,包括抑制新生血管生成、营养和保护神经元等。最近的研究表明PEDF能够通过抑制血管内皮生长因子(VEGF)的活性来抑制眼部血管的增生和肿瘤血管的生成,同时PEDF还能通过多种信号通路抑制神经退行性病变的发生。文章就PEDF的多种生物学活性以及发挥作用的相关信号通路做一综述,另外结合PEDF的受体深入探讨了其发挥生物学活性的可能机制。更多还原

【Abstract】 Pigment epithelium-derived factor( PEDF) is an endogenously produced protein widely expressed throughout the human body,which exhibits multiple and varied biological actions. Over the past few years,PEDF has been described as a multifaceted protein with anti-angiogenic,neurotrophic,neuroprotective,and anti-permeability. PEDF effectively inhibits vascular endothelial growth factor( VEGF)-driven angiogenesis and vascular permeability by regulating the intracellular proteolysis of VEGF receptors in recent reports. Moreover,PEDF can inhibit the occurrence of neural degenerative diseases through a variety of signaling pathways. The aim of the present review is to discuss the varied biological actions of PEDF and to identify the possible molecular mechanism underlying its effects.更多还原