【摘要】 糖是自然界种类最丰富、结构最多样的一类生物分子,参与了许多重要的生命过程.糖在生物体内通常以糖脂、糖蛋白等缀合物的形式存在,发挥着十分重要的生物学作用.氮连接聚糖(N-linked glycan)是糖蛋白的重要组成部分,但是在自然界中通常以微观非均一的形式存在,均一结构的糖链难以获取,这极大地阻碍了糖科学的相关研究.化学合成是获取均一结构聚糖、进而用以研究其生物学功能的重要手段.本综述着重总结了通过化学方法制备真核蛋白质中最为常见的一类糖链——复杂型氮连接聚糖的最新研究进展.更多还原

【Abstract】 Carbohydrates are the most abundant and structurally diverse class of biomolecules, which were involved in various biological processes. Carbohydrates play crucial roles in biological systems, and mostly exist in the forms of glycoproteins, glycolipids, and other glycoconjugates. N-linked glycans are essential components of glycoproteins, but are difficult to be obtained in homogeneous forms from natural sources, creating formidable challenges to the research in related fields such as glycobiology. Chemical synthesis represents an important approach for preparing homogeneous carbohydrates, which greatly benefits the study of glycan functions. In this review, we highlight recent advances in the chemical synthesis of complex-type N-glycans that frequently present on eukaryotic proteins with essential biological functions.更多还原