【摘要】 目的探讨降钙素原(procalcitonin,PCT)、血清D-二聚体与肺癌的相关性。方法选取近两年来就诊的肺癌患者166例和同期健康患者或不患有肺部疾病患者166例,采用Spearman秩相关,Logistic剂量反应关系和交互作用研究它们之间的相关性。结果年龄、降钙素原(procalcitonin,PCT)、癌胚抗原(carcinoembryonicantigen,CEA)、D-二聚体与肺癌存在相关性(rs分别为0.289、0.262、0.387和-0.161)。年龄(≥60岁)(OR=2.53,95%CI:1.28~5.00,P=0.008)、PCT异常(OR=2.10,95%CI:1.07~4.14,P=0.032)、CEA异常(OR=11.68,95%CI:4.57~29.82,P=0.001)和D-二聚体异常(OR=1.43,95%CI:1.15~1.68,P=0.001)均是肺癌的影响因素。随着PCT和D-二聚体水平的增加,肺癌患者的危险性增高,呈现一定的剂量反应关系(均有P<0.05)。PCT与D-二聚体间对肺癌具有正相加模型的交互作用,同时作用时会增加肺癌的患病风险(交互作用指数=2.16,95%CI:1.08~5.43;交互作用超额相对危险度=1.29,95%CI:0.68~2.71;交互作用归因比=0.75,95%CI:0.37~1.42)。结论 PCT与D-二聚体偏高是肺癌患者的危险因素,且存在剂量反应关系。PCT与D-二聚体存在正相加模型的交互作用,同时偏高时会增加肺癌的患病风险。更多还原

【Abstract】 Objective To investigate the relationship between procalcitonin( PCT),serum D-dimer and lung cancer. Methods A total of 166 patients with lung cancer in the last two years and 166 concurrent healthy people or patients without lung diseases were selected. Spearman rank correlation,dose-response relationship of Logistic regression and interaction effect were used to study the correlations between PCT,D-dimer and lung cancer. Results The age,PCT,carcinoembryonic antigen( CEA) and D-dimer were correlated with lung cancer( rs= 0. 289,0. 262,0. 387 and 0. 161).Age( ≥60 years)( OR = 2. 53,95% CI: 1. 28-5. 00,P = 0. 008),PCT abnormalities( OR = 2. 10,95% CI: 1. 07-4. 14,P = 0. 032),CEA abnormalities( OR = 11. 68,95% CI: 4. 57-29. 82,P = 0. 001) and D-dimer abnormalities( OR = 1. 43,95% CI: 1. 15-1. 68,P = 0. 001) were influencing factors of lung cancer. With the increasing of PCT and Ddimer levels,the risk of lung cancer were increasing,which showed a positive dose-response relationship( all P < 0. 05).PCT and D-dimer had a positive additive model interaction with lung cancer,and at the same time increased the risk of lung cancer( interaction index = 2. 16,95% CI: 1. 08-5. 43; interaction the role of excess relative risk = 1. 29,95% CI 0. 68-2. 71; interaction attribution ratio = 0. 75,95% CI: 0. 37-1. 42). Conclusions High PCT and D-dimer are risk factors of lung cancer,and there is a significant dose-response relationship between them. Meanwhile,there is a positive additive interaction effect between PCT and D-dimer in an additive model,the risk of lung cancer will increase significantly when both of them are at an abnormal high level.更多还原